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  GABA quantitation using MEGA-PRESS: Regional and hemispheric differences

Grewal, M., Dabas, A., Saharan, S., Barker, P. B., Edden, R. A., & Mandal, P. K. (2016). GABA quantitation using MEGA-PRESS: Regional and hemispheric differences. Journal of Magnetic Resonance Imaging, 44(6), 1619-1623. doi:10.1002/jmri.25324.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-002E-A0A7-A Version Permalink: http://hdl.handle.net/21.11116/0000-0003-1C37-1
Genre: Journal Article

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 Creators:
Grewal, Monika1, Author
Dabas, Aroma1, Author              
Saharan, Sumiti1, Author
Barker, Peter B.1, Author
Edden, Richard A.E.1, Author
Mandal, Pravat K.1, Author
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1External Organizations, ou_persistent22              

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Free keywords: GABA; MEGA-PRESS; 1H-MRS; Frontal cortex; Parietal cortex; Occipital cortex
 Abstract: Purpose To measure in vivo brain gamma-aminobutyric acid (GABA) concentrations, and assess regional and hemispheric differences, using MR spectroscopy (1H-MRS). Materials and Methods GABA concentrations were measured bilaterally in the frontal cortex (FC), parietal cortex (PC), and occipital cortex (OC) of 21 healthy young subjects (age range 20–29 years) using 3 Tesla Philips scanner. A univariate general linear model analysis was carried out to assess the effect of region and hemisphere as well as their interaction on GABA concentrations while controlling for sex and gray matter differences. Results Results indicated a significant regional dependence of GABA levels [F(2,89) = 11.725, P < 0.001, inline image = .209] with lower concentrations in the FC compared with both PC (P < 0.001) and OC (P < 0.001) regions. There was no significant hemispheric differences in GABA levels [F(1,89) = .172; P = 0.679; inline image = .002]. Conclusion This study reports the concentrations of GABA in the FC, PC, and OC brain regions of healthy young adults. GABA distribution exhibits hemispheric symmetry, but varies across regions; GABA levels in the FC are lower than those in the PC and OC.

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Language(s): eng - English
 Dates: 2016-05-132016-04-082016-05-152016-06-052016-12
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1002/jmri.25324
PMID: 27264205
PMC: PMC5512099
Other: Epub 2016
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Title: Journal of Magnetic Resonance Imaging
Source Genre: Journal
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Publ. Info: Chicago, IL : Society for Magnetic Resonance Imaging
Pages: - Volume / Issue: 44 (6) Sequence Number: - Start / End Page: 1619 - 1623 Identifier: ISSN: 1053-1807
CoNE: https://pure.mpg.de/cone/journals/resource/954925594512