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  Connectome-harmonic decomposition of human brain activity reveals dynamical repertoire re-organization under LSD

Atasoy, S., Roseman, L., Kaelen, M., Kringelbach, M. L., Deco, G., & Carhart-Harris, R. L. (2017). Connectome-harmonic decomposition of human brain activity reveals dynamical repertoire re-organization under LSD. Scientific Reports, 7: 17661. doi:10.1038/s41598-017-17546-0.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-002E-A1F9-8 Version Permalink: http://hdl.handle.net/21.11116/0000-0003-BCE1-B
Genre: Journal Article

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 Creators:
Atasoy, Selen1, Author
Roseman, Leor2, Author
Kaelen, Mendel2, Author
Kringelbach, Morten L.3, 4, Author
Deco, Gustavo1, 5, 6, 7, Author              
Carhart-Harris, Robin L.2, Author
Affiliations:
1Center for Brain and Cognition, University Pompeu Fabra, Barcelona, Spain, ou_persistent22              
2Department of Medicine, King’s College London, United Kingdom, ou_persistent22              
3Department of Psychiatry, University of Oxford, United Kingdom, ou_persistent22              
4Center for Music in the Brain, Aarhus University, Denmark, ou_persistent22              
5Catalan Institution for Research and Advanced Studies (ICREA), University Pompeu Fabra, Barcelona, Spain, ou_persistent22              
6Department Neuropsychology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634551              
7School of Psychological Sciences, Monash University, Melbourne, Australia, ou_persistent22              

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 Abstract: Recent studies have started to elucidate the effects of lysergic acid diethylamide (LSD) on the human brain but the underlying dynamics are not yet fully understood. Here we used ’connectome-harmonic decomposition’, a novel method to investigate the dynamical changes in brain states. We found that LSD alters the energy and the power of individual harmonic brain states in a frequency-selective manner. Remarkably, this leads to an expansion of the repertoire of active brain states, suggestive of a general re-organization of brain dynamics given the non-random increase in co-activation across frequencies. Interestingly, the frequency distribution of the active repertoire of brain states under LSD closely follows power-laws indicating a re-organization of the dynamics at the edge of criticality. Beyond the present findings, these methods open up for a better understanding of the complex brain dynamics in health and disease.

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Language(s): eng - English
 Dates: 2017-07-262017-11-242017-12-15
 Publication Status: Published online
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1038/s41598-017-17546-0
PMID: 29247209
PMC: PMC5732294
 Degree: -

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Project name : Beatriu de Pinos-3 Postdoctoral Programme / BP3
Grant ID : 801370
Funding program : Horizon 2020
Funding organization : European Commission (EC)
Project name : -
Grant ID : -
Funding program : -
Funding organization : Beckley Foundation
Project name : The Dynamical and Structural Basis of Human Mind Complexity: Segregation and Integration of Information and Processing in the Brain / DYSTRUCTURE
Grant ID : 295129
Funding program : Funding Programme 7
Funding organization : European Commission (EC)
Project name : -
Grant ID : PSI2016-75688-P
Funding program : Spanish National Project Complexity of Brain States
Funding organization : Spanish Research Agency (AEI) and the European Regional Development Fund (ERDF)
Project name : Human Brain Project Specific Grant Agreement 1 / HBP SGA1
Grant ID : 720270
Funding program : Horizon 2020
Funding organization : European Commission (EC)
Project name : The plasticity of parental caregiving: characterizing the brain mechanisms underlying normal and disrupted development of parenting / CAREGIVING
Grant ID : 615539
Funding program : Funding Programme 7
Funding organization : European Commission (EC)

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Title: Scientific Reports
  Abbreviation : Sci. Rep.
Source Genre: Journal
 Creator(s):
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Publ. Info: London, UK : Nature Publishing Group
Pages: - Volume / Issue: 7 Sequence Number: 17661 Start / End Page: - Identifier: ISSN: 2045-2322
CoNE: /journals/resource/2045-2322