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  Techniques for blood volume fMRI with VASO: From low-resolution mapping towards sub-millimeter layer-dependent applications

Huber, L., Ivanov, D., Handwerker, D. A., Marrett, S., Guidi, M., Uludağ, K., et al. (2018). Techniques for blood volume fMRI with VASO: From low-resolution mapping towards sub-millimeter layer-dependent applications. NeuroImage, 164, 131-143. doi:10.1016/j.neuroimage.2016.11.039.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-002E-A263-1 Version Permalink: http://hdl.handle.net/21.11116/0000-0003-A2ED-B
Genre: Journal Article

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 Creators:
Huber, Laurentius1, Author
Ivanov, Dimo2, Author
Handwerker, Daniel A.1, Author
Marrett, Sean3, Author
Guidi, Maria4, Author              
Uludağ, Kâmil2, Author
Bandettini, Peter A.1, 3, Author
Poser, Benedikt A.2, Author
Affiliations:
1Section on Functional Imaging Methods, National Institute of Mental Health, Bethesda, MD, USA, ou_persistent22              
2Maastricht Brain Imaging Centre, Maastricht University, the Netherlands, ou_persistent22              
3Functional MRI Core Facility, National Institute of Mental Health, Bethesda, MD, USA, ou_persistent22              
4Methods and Development Unit Nuclear Magnetic Resonance, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634558              

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Free keywords: Vascular space occupancy; SS-SI VASO; Cerebral blood volume; Simultaneous multi-slice; 3D-EPI; 7 T MRI; Layer-dependent fMRI
 Abstract: Quantitative cerebral blood volume (CBV) fMRI has the potential to overcome several specific limitations of BOLD fMRI. It provides direct physiological interpretability and promises superior localization specificity in applications of sub-millimeter resolution fMRI applications at ultra-high magnetic fields (7 T and higher). Non-invasive CBV fMRI using VASO (vascular space occupancy), however, is inherently limited with respect to its data acquisition efficiency, restricting its imaging coverage and achievable spatial and temporal resolution. This limitation may be reduced with recent advanced acceleration and reconstruction strategies that allow two-dimensional acceleration, such as in simultaneous multi-slice (SMS) 2D-EPI or 3D-EPI in combination with CAIPIRINHA field-of-view shifting. In this study, we sought to determine the functional sensitivity and specificity of these readout strategies with VASO over a broad range of spatial resolutions; spanning from low spatial resolution (3 mm) whole-cortex to sub-millimeter (0.75 mm) slab-of-cortex (for cortical layer-dependent applications). In the thermal-noise-dominated regime of sub-millimeter resolutions, 3D-EPI-VASO provides higher temporal stability and sensitivity to detect changes in CBV compared to 2D-EPI-VASO. In this regime, 3D-EPI-VASO unveils task activation located in the cortical laminae with little contamination from surface veins, in contrast to the cortical surface weighting of GE-BOLD fMRI. In the physiological-noise-dominated regime of lower resolutions, however, 2D-SMS-VASO shows superior performance compared to 3D-EPI-VASO. Due to its superior sensitivity at a layer-dependent level, 3D-EPI VASO promises to play an important role in future neuroscientific applications of layer-dependent fMRI.

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Language(s): eng - English
 Dates: 2016-11-142016-11-182018-01-01
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1016/j.neuroimage.2016.11.039
PMID: 27867088
PMC: PMC5436958
Other: Epub 2016
 Degree: -

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Project name : -
Grant ID : ZIA-MH002783
Funding program : Intramural Research Program
Funding organization : National Institute of Mental Health (NIMH)
Project name : -
Grant ID : 452-11-002
Funding program : Vidi-Grant
Funding organization : Netherlands Organization for Scientific Research (NWO)
Project name : Ultra-High Field Magnetic Resonance Imaging / HIMR
Grant ID : 316716
Funding program : Funding Programme 7 (FP7-PEOPLE-2012-ITN)
Funding organization : European Commission (EC)

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Title: NeuroImage
Source Genre: Journal
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Affiliations:
Publ. Info: Orlando, FL : Academic Press
Pages: - Volume / Issue: 164 Sequence Number: - Start / End Page: 131 - 143 Identifier: ISSN: 1053-8119
CoNE: https://pure.mpg.de/cone/journals/resource/954922650166