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  Urinary Bladder Cancer in a Former Area of Underground Hard Coal Mining

Golka, K., Ovsiannikov, D., Blaszkewicz, M., Moormann, O., Haenel, M., Hengstler, J. G., et al. (2017). Urinary Bladder Cancer in a Former Area of Underground Hard Coal Mining. In M. Ibaraki, & H. Mori (Eds.), Progress in Medical Geology (pp. 214-228). Newcasle upon Tyne: Cambridge Scholars Publishing.

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 Creators:
Golka, Klaus1, Author
Ovsiannikov, Daniel2, 3, 4, Author
Blaszkewicz, Meinolf1, Author
Moormann, Oliver3, Author
Haenel, Matthias5, Author           
Hengstler, Jan G.1, Author
Selinski, Silvia1, Author
Affiliations:
1Leibniz Research Centre for Working Environment and Human Factors,TU Dortmund, Ardeystraße 67 44139 Dortmund, ou_persistent22              
2St.-Marien Hospital, Department of Urology, Luenen, Altstadtstraße 23, 44534 Lünen, ou_persistent22              
3St.-Josefs-Hospital Dortmund-Hoerde, Department of Urology, Dortmund, Wilhelm-Schmidt-Straße 4, 44263 Dortmund, ou_persistent22              
4Kemperhof Hospital, Department of Urology and Pediatric Urology, Koblenz, Koblenzer Straße 115-155 56073 Koblenz , ou_persistent22              
5Research Group Haenel, Max-Planck-Institut für Kohlenforschung, Max Planck Society, ou_1445604              

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Free keywords: urinary bladder cancer, coal mining, glutathione S-transferase M1 (GSTM1), N-acetyltransferase 2 (NAT2), xenobiotic metabolizing enzymes, susceptibility factors for urinary bladder cancer
 Abstract: Urinary bladder cancer in coal miners is currently under debate. We report on a recently performed study on 196 bladder cancer cases (80% male) from Dortmund, a centre of the former underground hard coal mining industry in Germany. A total of 235 controls (77% male), with benign urological diseases but without a history of malignancies, were assessed by questionnaire from July 2009 to December 2010. From the sample, there were twenty bladder cancer cases (10%) and 8 controls (3%) who had an occupational history of hard coal mining (OR 3.22, 95% CI 1.39 - 7.49; brown coal mining: 2 cases, no control). During the late 1940s and 1950s, the average working life for hard coal miners was less than 20 years. These findings are consistent with an earlier study in this area on 412 male bladder cancer patients and 414 controls with benign prostatic hyperplasia that were investigated from 1984 to 1988. The study presented a smoking-adjusted odds ratio for bladder cancer of 2.54 (95% CI 1.64 - 3.93). Aromatic amines were not found to be a constituent of hard coal. Furthermore, the slow N-acetyltransferase 2 status, which is associated with an increased bladder cancer risk in persons formerly exposed to aromatic amines, was normal in hard coal miners with bladder cancer in two studies in the Dortmund area. The results of the studies in the Dortmund area indicate that the increased bladder cancer risk in underground hard coal minrs was not caused by exposure to carcinogenic aromatic amines.

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Language(s): eng - English
 Dates: 2017-05
 Publication Status: Published in print
 Pages: 15
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: -
 Degree: -

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Title: Progress in Medical Geology
Source Genre: Book
 Creator(s):
Ibaraki, Motomu1, Editor
Mori, Hiroko1, Editor
Affiliations:
1 Ohio State University, 275 Mendenhall Lab, 125 South Oval Mall, Columbus OH, 43210, ou_persistent22            
Publ. Info: Newcasle upon Tyne : Cambridge Scholars Publishing
Pages: 340 Volume / Issue: - Sequence Number: - Start / End Page: 214 - 228 Identifier: ISBN: 978-1-4438-7319-2