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  A pathway from midcingulate cortex to posterior insula gates nociceptive hypersensitivity

Tan, L. L., Pelzer, P., Heinl, C., Tang, W., Gangadharan, V., Flor, H., et al. (2017). A pathway from midcingulate cortex to posterior insula gates nociceptive hypersensitivity. Nature Neuroscience, 20, 1591-1601. doi:10.1038/nn.4645.

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Item Permalink: https://hdl.handle.net/21.11116/0000-0000-2AEC-8 Version Permalink: https://hdl.handle.net/21.11116/0000-0000-2AED-7
Genre: Journal Article

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 Creators:
Tan, Linette Liqi, Author
Pelzer, Patric, Author
Heinl, Céline, Author
Tang, Wannan1, Author           
Gangadharan, Vijayan, Author
Flor, Herta, Author
Sprengel, Rolf1, Author           
Kuner, Thomas, Author
Kuner, Rohini, Author
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1Department of Molecular Neurobiology, Max Planck Institute for Medical Research, Max Planck Society, ou_1497704              

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 Abstract: The identity of cortical circuits mediating nociception and pain is largely unclear. The cingulate cortex is consistently activated during pain, but the functional specificity of cingulate divisions, the roles at distinct temporal phases of central plasticity and the underlying circuitry are unknown. Here we show in mice that the midcingulate division of the cingulate cortex (MCC) does not mediate acute pain sensation and pain affect, but gates sensory hypersensitivity by acting in a wide cortical and subcortical network. Within this complex network, we identified an afferent MCC-posterior insula pathway that can induce and maintain nociceptive hypersensitivity in the absence of conditioned peripheral noxious drive. This facilitation of nociception is brought about by recruitment of descending serotonergic facilitatory projections to the spinal cord. These results have implications for our understanding of neuronal mechanisms facilitating the transition from acute to long-lasting pain.

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Language(s): eng - English
 Dates: 2016-06-102017-08-152017-09-182017-11
 Publication Status: Issued
 Pages: 16
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 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1038/nn.4645
URI: https://www.ncbi.nlm.nih.gov/pubmed/28920932
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Title: Nature Neuroscience
  Other : Nat. Neurosci.
Source Genre: Journal
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Publ. Info: New York, NY : Nature America Inc.
Pages: - Volume / Issue: 20 Sequence Number: - Start / End Page: 1591 - 1601 Identifier: ISSN: 1097-6256
CoNE: https://pure.mpg.de/cone/journals/resource/954925610931