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  18F‑Deoxyfluorination of Phenols via Ru π‑Complexes

Beyzavi, M. H., Mandal, D., Strebl, M. G., Neumann, C. N., D'Amato, E. M., Chen, J., et al. (2017). 18F‑Deoxyfluorination of Phenols via Ru π‑Complexes. ACS Central Science, 3(9), 944-948. doi:10.1021/acscentsci.7b00195.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0000-77A1-4 Version Permalink: http://hdl.handle.net/21.11116/0000-0000-77A2-3
Genre: Journal Article

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 Creators:
Beyzavi, M. Hassan1, 2, Author
Mandal, Debashis1, Author
Strebl, Martin G.1, 2, Author
Neumann, Constanze N.1, Author
D'Amato, Erica M.1, Author
Chen, Junting3, Author
Hooker, Jacob M.2, 4, Author
Ritter, Tobias1, 3, 4, Author              
Affiliations:
1Department of Chemistry and Chemical Biology, Harvard University, 12 Oxford Street, Cambridge, Massachusetts 02138, United States , ou_persistent22              
2Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts 02129, United States, ou_persistent22              
3Research Department Ritter, Max-Planck-Institut für Kohlenforschung, Max Planck Society, ou_2040308              
4Division of Nuclear Medicine and Molecular Imaging, Department of Radiology, Massachusetts General Hospital, Boston, Massachusetts 02144, United States, ou_persistent22              

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 Abstract: The deficiency of robust and practical methods for 18F-radiofluorination is a bottleneck for positron emission tomography (PET) tracer development. Here, we report the first transition-metal-assisted 18F-deoxyfluorination of phenols. The transformation benefits from readily available phenols as starting materials, tolerance of moisture and ambient atmosphere, large substrate scope, and translatability to generate doses appropriate for PET imaging.

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Language(s): eng - English
 Dates: 2017-05-042017-08-032017-09-27
 Publication Status: Published in print
 Pages: 5
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1021/acscentsci.7b00195
 Degree: -

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Title: ACS Central Science
  Other : ACS Cent. Sci.
Source Genre: Journal
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Publ. Info: Washington : American Chemical Society
Pages: - Volume / Issue: 3 (9) Sequence Number: - Start / End Page: 944 - 948 Identifier: ISSN: 2374-7943
CoNE: /journals/resource/2374-7951