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  Determination of urinary metabolites of the emerging UV filter octocrylene by online-SPE-LC-MS/MS.

Bury, D., Belov, V. N., Qi, Y., Hayen, H., Volmer, D. A., Bruning, T., et al. (2018). Determination of urinary metabolites of the emerging UV filter octocrylene by online-SPE-LC-MS/MS. Analytical Chemistry, 90(1), 944-951. doi:10.1021/acs.analchem.7b03996.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0000-3212-3 Version Permalink: http://hdl.handle.net/21.11116/0000-0003-45D6-E
Genre: Journal Article

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Bury, D., Author
Belov, V. N.1, Author              
Qi, Y., Author
Hayen, H., Author
Volmer, D. A., Author
Bruning, T., Author
Koch, H. M., Author
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1Department of NanoBiophotonics, MPI for biophysical chemistry, Max Planck Society, ou_578627              

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 Abstract: Octocrylene (OC) is an emerging UV filter, which is used in the majority of sunscreens as well as other personal care products (PCP) and consumer products. Its presence in various environmental matrices has been reported. However, information on the internal OC exposure in humans is not available, due to the lack of appropriate biomarkers of exposure and analytical methods. Here, we describe a rugged, precise, and accurate analytical method for the determination of three OC metabolites (ester hydrolysis and alkyl chain oxidation products) in human urine by stable isotope dilution analysis. Urine samples are incubated with β-glucuronidase (E. coli K12) and then analyzed by liquid chromatography-electrospray ionization-triple quadrupole-tandem mass spectrometry with online turbulent flow chromatography for sample cleanup and analyte enrichment (online-SPE-LC-MS/MS). Syntheses of analytical standards, including deuterium-labeled internal standards, are also described. In a pilot study, we investigated the applicability of the metabolites as biomarkers of exposure in urine samples from the general population (n = 35). OC metabolites were detected in 91% of the samples, with the highest concentrations for three individuals having used sunscreen within 5 days prior to sample collection. We will apply the method in future human biomonitoring studies for OC exposure and risk assessment.

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Language(s): eng - English
 Dates: 2017-11-302018-01-02
 Publication Status: Published in print
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 Rev. Method: Peer
 Identifiers: DOI: 10.1021/acs.analchem.7b03996
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Title: Analytical Chemistry
Source Genre: Journal
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Pages: - Volume / Issue: 90 (1) Sequence Number: - Start / End Page: 944 - 951 Identifier: -