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  Stereotypical architecture of the stem cell niche is spatiotemporally established by miR-125-dependent coordination of Notch and steroid signaling.

Yatsenko, A. S., & Shcherbata, H. R. (2018). Stereotypical architecture of the stem cell niche is spatiotemporally established by miR-125-dependent coordination of Notch and steroid signaling. Development, 145(3): dev159178. doi:10.1242/dev.159178.

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 Urheber:
Yatsenko, A. S.1, Autor           
Shcherbata, H. R.1, Autor           
Affiliations:
1Research Group of Gene Expression and Signaling, MPI for biophysical chemistry, Max Planck Society, ou_578608              

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Schlagwörter: Drosophila, Oogenesis, Germline stem cell, Stem cell niche, Cell fate, Steroid, miR-125, Tom, Notch, Delta, Notch cell reprogramming
 Zusammenfassung: Stem cell niches act as signaling platforms that regulate stem cell self-renewal and sustain stem cells throughout life; however, the specific developmental events controlling their assembly are not well understood. Here we show that during Drosophila ovarian germline stem cell niche formation, the status of Notch signaling in the cell can be reprogrammed. This is controlled via steroid-induced miR-125, which targets a negative regulator of Notch signaling, Tom. Thus, miR-125 acts as a spatiotemporal coordinator between paracrine Notch and endocrine steroid signaling. Moreover, a dual security mechanism for Notch signaling activation exists to ensure the robustness of niche assembly. Particularly, stem cell niche cells can be specified either via lateral inhibition, in which a niche cell precursor acquires Notch signal-sending status randomly, or via peripheral induction, whereby Delta is produced by a specific cell. When one mechanism is perturbed due to mutations, developmental defects, or environmental stress, the remaining mechanism ensures that the niche is formed, perhaps abnormal but still functional. This guarantees that the germline stem cells will have their residence, thereby securing progressive oogenesis, thus, organism reproduction.

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Sprache(n): eng - English
 Datum: 2018-01-222018-02-08
 Publikationsstatus: Erschienen
 Seiten: -
 Ort, Verlag, Ausgabe: -
 Inhaltsverzeichnis: -
 Art der Begutachtung: Expertenbegutachtung
 Identifikatoren: DOI: 10.1242/dev.159178
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Titel: Development
Genre der Quelle: Zeitschrift
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Ort, Verlag, Ausgabe: -
Seiten: 13 Band / Heft: 145 (3) Artikelnummer: dev159178 Start- / Endseite: - Identifikator: -