English
 
User Manual Privacy Policy Disclaimer Contact us
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
  Stereotypical architecture of the stem cell niche is spatiotemporally established by miR-125-dependent coordination of Notch and steroid signaling.

Yatsenko, A. S., & Shcherbata, H. R. (2018). Stereotypical architecture of the stem cell niche is spatiotemporally established by miR-125-dependent coordination of Notch and steroid signaling. Development, 145(3): dev159178. doi:10.1242/dev.159178.

Item is

Basic

show hide
Item Permalink: http://hdl.handle.net/21.11116/0000-0000-3505-F Version Permalink: http://hdl.handle.net/21.11116/0000-0003-C242-7
Genre: Journal Article

Files

show Files
hide Files
:
2527268.pdf (Publisher version), 8MB
Name:
2527268.pdf
Description:
-
Visibility:
Public
MIME-Type / Checksum:
application/pdf / [MD5]
Technical Metadata:
Copyright Date:
-
Copyright Info:
-

Locators

show

Creators

show
hide
 Creators:
Yatsenko, A. S.1, Author              
Shcherbata, H. R.1, Author              
Affiliations:
1Research Group of Gene Expression and Signaling, MPI for biophysical chemistry, Max Planck Society, ou_578608              

Content

show
hide
Free keywords: Drosophila, Oogenesis, Germline stem cell, Stem cell niche, Cell fate, Steroid, miR-125, Tom, Notch, Delta, Notch cell reprogramming
 Abstract: Stem cell niches act as signaling platforms that regulate stem cell self-renewal and sustain stem cells throughout life; however, the specific developmental events controlling their assembly are not well understood. Here we show that during Drosophila ovarian germline stem cell niche formation, the status of Notch signaling in the cell can be reprogrammed. This is controlled via steroid-induced miR-125, which targets a negative regulator of Notch signaling, Tom. Thus, miR-125 acts as a spatiotemporal coordinator between paracrine Notch and endocrine steroid signaling. Moreover, a dual security mechanism for Notch signaling activation exists to ensure the robustness of niche assembly. Particularly, stem cell niche cells can be specified either via lateral inhibition, in which a niche cell precursor acquires Notch signal-sending status randomly, or via peripheral induction, whereby Delta is produced by a specific cell. When one mechanism is perturbed due to mutations, developmental defects, or environmental stress, the remaining mechanism ensures that the niche is formed, perhaps abnormal but still functional. This guarantees that the germline stem cells will have their residence, thereby securing progressive oogenesis, thus, organism reproduction.

Details

show
hide
Language(s): eng - English
 Dates: 2018-01-222018-02-08
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1242/dev.159178
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: Development
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: -
Pages: 13 Volume / Issue: 145 (3) Sequence Number: dev159178 Start / End Page: - Identifier: -