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  The role of recombination in evolutionary rescue

Uecker, H., & Hermisson, J. (2016). The role of recombination in evolutionary rescue. Genetics, 202(2), 721-732. doi:10.1534/genetics.115.180299.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0000-3A08-7 Version Permalink: http://hdl.handle.net/21.11116/0000-0000-3A09-6
Genre: Journal Article

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Uecker, Hildegard1, Author              
Hermisson, Joachim, Author
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1External Organizations, ou_persistent22              

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Free keywords: RAPID ADAPTATION; EPISTASIS; DRIFT; POPULATION DYNAMICS; ECOLOGY
 Abstract: How likely is it that a population escapes extinction through adaptive evolution? The answer to this question is of great relevance in conservation biology, where we aim at species’ rescue and the maintenance of biodiversity, and in agriculture and medicine, where we seek to hamper the emergence of pesticide or drug resistance. By reshuffling the genome, recombination has two antagonistic effects on the probability of evolutionary rescue: it generates and it breaks up favorable gene combinations. Which of the two effects prevails depends on the fitness effects of mutations and on the impact of stochasticity on the allele frequencies. In this article, we analyze a mathematical model for rescue after a sudden environmental change when adaptation is contingent on mutations at two loci. The analysis reveals a complex nonlinear dependence of population survival on recombination. We moreover find that, counterintuitively, a fast eradication of the wild type can promote rescue in the presence of recombination. The model also shows that two-step rescue is not unlikely to happen and can even be more likely than single-step rescue (where adaptation relies on a single mutation), depending on the circumstances.

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Language(s): eng - English
 Dates: 2015-07-052015-11-162015-12-012016
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: -
 Identifiers: DOI: 10.1534/genetics.115.180299
BibTex Citekey: Uecker721
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Title: Genetics
Source Genre: Journal
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Publ. Info: Genetics Society of America
Pages: - Volume / Issue: 202 (2) Sequence Number: - Start / End Page: 721 - 732 Identifier: ISSN: 0016-6731
CoNE: /journals/resource/954925400554