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  Adaptive gene introgression after secondary contact

Uecker, H., Setter, D., & Hermisson, J. (2015). Adaptive gene introgression after secondary contact. Journal of Mathematical Biology, 70(7), 1523-1580. doi:10.1007/s00285-014-0802-y.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0000-3A1C-1 Version Permalink: http://hdl.handle.net/21.11116/0000-0000-3EFF-D
Genre: Journal Article

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 Creators:
Uecker, Hildegard1, Author              
Setter, Derek, Author
Hermisson, Joachim, Author
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1External Organizations, ou_persistent22              

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Free keywords: Branching processes; Gene introgression; Adaptation; Hybridization; Genetic hitchhiking
 Abstract: By hybridization and backcrossing, alleles can surmount species boundaries and be incorporated into the genome of a related species. This introgression of genes is of particular evolutionary relevance if it involves the transfer of adaptations between populations. However, any beneficial allele will typically be associated with other alien alleles that are often deleterious and hamper the introgression process. In order to describe the introgression of an adaptive allele, we set up a stochastic model with an explicit genetic makeup of linked and unlinked deleterious alleles. Based on the theory of reducible multitype branching processes, we derive a recursive expression for the establishment probability of the beneficial allele after a single hybridization event. We furthermore study the probability that slightly deleterious alleles hitchhike to fixation. The key to the analysis is a split of the process into a stochastic phase in which the advantageous alleles establishes and a deterministic phase in which it sweeps to fixation. We thereafter apply the theory to a set of biologically relevant scenarios such as introgression in the presence of many unlinked or few closely linked deleterious alleles. A comparison to computer simulations shows that the approximations work well over a large parameter range.

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Language(s): eng - English
 Dates: 2014-05-212013-12-032014-07-042015
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: -
 Identifiers: DOI: 10.1007/s00285-014-0802-y
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Title: Journal of Mathematical Biology
Source Genre: Journal
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Publ. Info: Heidelberg : Springer
Pages: 58 Volume / Issue: 70 (7) Sequence Number: - Start / End Page: 1523 - 1580 Identifier: ISSN: 0303-6812
CoNE: /journals/resource/954925511424