English
 
User Manual Privacy Policy Disclaimer Contact us
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
  Response transformation and receptive-field synthesis in the lemniscal trigeminothalamic circuit

Minnery, B. S., Bruno, R. M., & Simons, D. J. (2003). Response transformation and receptive-field synthesis in the lemniscal trigeminothalamic circuit. Journal of Neurophysiology, 90(3), 1556-1570. doi:10.1152/jn.00111.2003.

Item is

Basic

show hide
Item Permalink: http://hdl.handle.net/21.11116/0000-0000-3C0D-0 Version Permalink: http://hdl.handle.net/21.11116/0000-0000-3C0E-F
Genre: Journal Article

Files

show Files
hide Files
:
JNeurophysiol_90_2003_1556.pdf (Any fulltext), 408KB
 
File Permalink:
-
Name:
JNeurophysiol_90_2003_1556.pdf
Description:
-
Visibility:
Restricted (Max Planck Institute for Medical Research, MHMF; )
MIME-Type / Checksum:
application/pdf
Technical Metadata:
Copyright Date:
-
Copyright Info:
-
License:
-

Locators

show
hide
Description:
-
Locator:
https://doi.org/10.1152/jn.00111.2003 (Any fulltext)
Description:
-

Creators

show
hide
 Creators:
Minnery, Brandon S., Author
Bruno, Randy M.1, 2, Author              
Simons, Daniel J., Author
Affiliations:
1Department of Cell Physiology, Max Planck Institute for Medical Research, Max Planck Society, ou_1497701              
2Whisker Representation, Max Planck Institute for Medical Research, Max Planck Society, ou_1497747              

Content

show
hide
Free keywords: Metrics
 Abstract: To understand how the lemniscal trigeminothalamic circuit (PrV --> VPM) of the rodent whisker-to-barrel pathway transforms afferent signals, we applied ramp-and-hold deflections to individual whiskers of lightly narcotized rats while recording the extracellular responses of neurons in either the ventroposterior medial (VPM) thalamic nucleus or in brain stem nucleus principalis (PrV). In PrV, only those neurons antidromically determined to project to VPM were selected for recording. We found that VPM neurons exhibited smaller response magnitudes and greater spontaneous firing rates than those of their PrV inputs, but that both populations were similarly well tuned for stimulus direction. In addition, fewer VPM (74%) than PrV neurons (93%) responded with sustained, or tonic, discharges during the plateau phase of the stimulus. Neurons in both populations responded most robustly to deflections of a single, "principal whisker" (PW), and the majority of cells in both PrV (90%) and VPM (73%) also responded to deflections of at least one adjacent whisker (AW). AW responses in both nuclei occurred on average at longer latencies and were more temporally dispersed than PW responses. Lateral inhibition, as evidenced by AW-evoked activity suppression, was rare in PrV but prevalent in VPM. In both nuclei, however, suppression was weak, with AW responses being on average excitatory. Our results suggest that the receptive-field structures and response properties of individual VPM neurons can be explained in large part by input from one or a small number of PrV neurons, but that intrathalamic mechanisms act to further transform the afferent signal.

Details

show
hide
Language(s): eng - English
 Dates: 2003-02-052003-04-252003-04-302003-09-01
 Publication Status: Published in print
 Pages: 15
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: Journal of Neurophysiology
  Other : J. Neurophysiol.
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: Bethesda, MD : The Society
Pages: - Volume / Issue: 90 (3) Sequence Number: - Start / End Page: 1556 - 1570 Identifier: ISSN: 0022-3077
CoNE: https://pure.mpg.de/cone/journals/resource/954925416959