English
 
Help Privacy Policy Disclaimer
  Advanced SearchBrowse
  1. Item Summary / 
  2. View item

Item

ITEM ACTIONSEXPORT
Add to Basket
 Local TagsRelease HistoryDetailsSummary
  Tumour-associated changes in intestinal epithelial cells cause local accumulation of KLRG1+ GATA3+ regulatory T cells in mice

Meinicke, H., Bremser, A., Brack, M., Akeus, P., Pearson, C., Bullers, S., et al. (2017). Tumour-associated changes in intestinal epithelial cells cause local accumulation of KLRG1+ GATA3+ regulatory T cells in mice. Immunology, 74-88. doi:10.1111/imm.12750.

Item is

 

show all hide all

Basic

show hide
Item Permalink: https://hdl.handle.net/21.11116/0000-0000-BF72-9 Version Permalink: https://hdl.handle.net/21.11116/0000-0008-9A6B-3
Genre: Journal Article

Files

show Files

Locators

show
hide
Locator:
https://onlinelibrary.wiley.com/doi/full/10.1111/imm.12750 (Publisher version)
Description:
-
OA-Status:

Creators

show
hide
 Creators:
Meinicke, Holger1, 2, Author
Bremser, Anna1, Author
Brack, Maria1, 2, Author
Akeus, Paulina2, Author
Pearson, Claire2, Author
Bullers, Samuel2, Author
Hoffmeyer, Katrin1, Author
Stemmler, Marc P.1, Author
Quiding-Järbrink, Marianne2, Author
Izcue, Ana1, Author
Affiliations:
1Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society, 79108 Freiburg, DE, ou_2243640              
2External Organizations, ou_persistent22              

Content

show
hide
Free keywords: cell surface molecules, mucosa, regulatory T cells, tumour immunology
 Abstract: CD4+ Foxp3+ regulatory T (Treg) cells include differentiated populations of effector Treg cells characterized by the expression of specific transcription factors. Tumours, including intestinal malignancies, often present with local accumulation of Treg cells that can prevent tumour clearance, but how tumour progression leads to Treg cell accumulation is incompletely understood. Here using genetically modified mouse models we show that ablation of E-cadherin, a process associated with epithelial to mesenchymal transition and tumour progression, promotes the accumulation of intestinal Treg cells by the specific accumulation of the KLRG1+ GATA3+ Treg subset. Epithelial E-cadherin ablation activates the β-catenin pathway, and we find that increasing β-catenin signals in intestinal epithelial cells also boosts Treg cell frequencies through local accumulation of KLRG1+ GATA3+ Treg cells. Both E-cadherin ablation and increased β-catenin signals resulted in epithelial cells with higher levels of interleukin-33, a cytokine that preferentially expands KLRG1+ GATA3+ Treg cells. Tumours often present reduced E-cadherin expression and increased β-catenin signalling and interleukin-33 production. Accordingly, Treg cell accumulation in intestinal tumours from APCmin/+ mice was exclusively due to the increase in KLRG1+ GATA3+Treg cells. Our data identify a novel axis through which epithelial cells control local Treg cell subsets, which may be activated during intestinal tumorigenesis.

Details

show
hide
Language(s): eng - English
 Dates: 2017-04-24
 Publication Status: Published online
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1111/imm.12750
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: Immunology
  Other : Immunology
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: Oxford : Blackwell Scientific Publications.
Pages: - Volume / Issue: - Sequence Number: - Start / End Page: 74 - 88 Identifier: ISSN: 0019-2805
CoNE: https://pure.mpg.de/cone/journals/resource/954925405692