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  Defining B Cell Chromatin: Lessons from EBF1

Boller, S., Li, R., & Grosschedl, R. (2018). Defining B Cell Chromatin: Lessons from EBF1. Trends in Genetics, 257-269. doi:10.1016/j.tig.2017.12.014.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0001-4A45-F Version Permalink: http://hdl.handle.net/21.11116/0000-0001-4A46-E
Genre: Journal Article

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 Creators:
Boller, Sören1, Author
Li, Rui1, Author
Grosschedl, Rudi1, Author
Affiliations:
1Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society, 79108 Freiburg, DE, ou_2243640              

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 Abstract: Hematopoiesis is regulated by signals from the microenvironment, transcription factor networks, and changes of the epigenetic landscape. Transcription factors interact with and shape chromatin to allow for lineage- and cell type-specific changes in gene expression. During B lymphopoiesis, epigenetic regulation is observed in multilineage progenitors in which a specific chromatin context is established, at the onset of the B cell differentiation when early B cell factor 1 (EBF1) induces lineage-specific changes in chromatin, during V(D)J recombination and after antigen-driven activation of B cells and terminal differentiation. In this review, we discuss the epigenetic changes underlying B cell differentiation, focusing on the role of transcription factor EBF1 in B cell lineage priming.

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Language(s): eng - English
 Dates: 20182018-04
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1016/j.tig.2017.12.014
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Title: Trends in Genetics
  Other : Trends Genet.
Source Genre: Journal
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Publ. Info: Elsevier Current Trends
Pages: - Volume / Issue: - Sequence Number: - Start / End Page: 257 - 269 Identifier: ISSN: 0168-9525
CoNE: /journals/resource/954925485719