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  Becoming a new neuron in the adult olfactory bulb

Carleton, A., Petreanu, L. T., Lansford, R., Alvarez−Buylla, A., & Lledo, P. (2003). Becoming a new neuron in the adult olfactory bulb. Nature Neuroscience, 6(5), 507-518. doi:10.1038/nn1048.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0000-3CC4-0 Version Permalink: http://hdl.handle.net/21.11116/0000-0000-3CC5-F
Genre: Journal Article

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 Creators:
Carleton, Alan1, 2, Author              
Petreanu, Leopoldo T., Author
Lansford, Rusty, Author
Alvarez−Buylla, Arturo, Author
Lledo, Pierre−Marie, Author
Affiliations:
1Olfaction Web, Max Planck Institute for Medical Research, Max Planck Society, ou_1497733              
2Department of Cell Physiology, Max Planck Institute for Medical Research, Max Planck Society, ou_1497701              

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 Abstract: New neurons are continually recruited throughout adulthood in certain regions of the adult mammalian brain. How these cells mature and integrate into preexisting functional circuits remains unknown. Here we describe the physiological properties of newborn olfactory bulb interneurons at five different stages of their maturation in adult mice. Patch-clamp recordings were obtained from tangentially and radially migrating young neurons and from neurons in three subsequent maturation stages. Tangentially migrating neurons expressed extrasynaptic GABA(A) receptors and then AMPA receptors, before NMDA receptors appeared in radially migrating neurons. Spontaneous synaptic activity emerged soon after migration was complete, and spiking activity was the last characteristic to be acquired. This delayed excitability is unique to cells born in the adult and may protect circuits from uncontrolled neurotransmitter release and neural network disruption. Our results show that newly born cells recruited into the olfactory bulb become neurons, and a unique sequence of events leads to their functional integration.

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Language(s): eng - English
 Dates: 2003-02-062003-03-112003-04-212003-05-01
 Publication Status: Published in print
 Pages: 12
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 Table of Contents: -
 Rev. Type: Peer
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Title: Nature Neuroscience
  Other : Nat. Neurosci.
Source Genre: Journal
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Publ. Info: New York, NY : Nature America Inc.
Pages: - Volume / Issue: 6 (5) Sequence Number: - Start / End Page: 507 - 518 Identifier: ISSN: 1097-6256
CoNE: https://pure.mpg.de/cone/journals/resource/954925610931