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  Crystal structure of the plasmid maintenance system ε /ζ : Functional mechanism of toxin ζ and inactivation by ε 2ζ 2 complex formation

Meinhart, A., Alonso, J. C., Sträter, N., & Saenger, W. (2003). Crystal structure of the plasmid maintenance system ε /ζ: Functional mechanism of toxin ζ and inactivation by ε 2ζ 2 complex formation. Proceedings of the National Academy of Sciences of the United States of America, 100(4), 1661-1666. doi:10.1073/pnas.0434325100.

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Datensatz-Permalink: https://hdl.handle.net/21.11116/0000-0000-3D6A-6 Versions-Permalink: https://hdl.handle.net/21.11116/0000-0000-3D6B-5
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PNAS_100_2003_1661.pdf (beliebiger Volltext), 915KB
 
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http://www.pnas.org/content/100/4/1661.full.pdf (beliebiger Volltext)
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https://doi.org/10.1073/pnas.0434325100 (beliebiger Volltext)
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 Urheber:
Meinhart, Anton1, 2, Autor           
Alonso, Juan C., Autor
Sträter, Norbert, Autor
Saenger, Wolfram, Autor
Affiliations:
1mRNA Processing, Max Planck Institute for Medical Research, Max Planck Society, ou_1497729              
2Department of Biomolecular Mechanisms, Max Planck Institute for Medical Research, Max Planck Society, ou_1497700              

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Schlagwörter: programmed cell death;varε protein; ζ protein; toxin inactivation; phosphotransferase
 Zusammenfassung: Programmed cell death in prokaryotes is frequently found as postsegregational killing. It relies on antitoxin/toxin systems that secure stable inheritance of low and medium copy number plasmids during cell division and kill cells that have lost the plasmid. The broad-host-range, low-copy-number plasmid pSM19035 from Streptococcus pyogenes carries the genes encoding the antitoxin/toxin system ɛ/ζ and antibiotic resistance proteins, among others. The crystal structure of the biologically nontoxic ɛ2ζ2 protein complex at a 1.95-Å resolution and site-directed mutagenesis showed that free ζ acts as phosphotransferase by using ATP/GTP. In ɛ2ζ2, the toxin ζ is inactivated because the N-terminal helix of the antitoxin ɛ blocks the ATP/GTP-binding site. To our knowledge, this is the first prokaryotic postsegregational killing system that has been entirely structurally characterized.

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Sprache(n): eng - English
 Datum: 2002-07-222002-12-202003-02-18
 Publikationsstatus: Erschienen
 Seiten: 6
 Ort, Verlag, Ausgabe: -
 Inhaltsverzeichnis: -
 Art der Begutachtung: Expertenbegutachtung
 Identifikatoren: DOI: 10.1073/pnas.0434325100
URI: http://www.pnas.org/cgi/content/abstract/100/4/1661?maxtoshow%3D%26HITS%3D10%26hits%3D10%26RESULTFORMAT%3D1%26andorexacttitle%3Dand%26andorexacttitleabs%3Dand%26andorexactfulltext%3Dand%26searchid%3D1102521677308_8179%26stored_search%3D%26FIRSTINDEX%3D0%26sortspec%3Drelevance%26volume%3D100%26firstpage
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Titel: Proceedings of the National Academy of Sciences of the United States of America
  Andere : Proceedings of the National Academy of Sciences of the USA
  Andere : Proc. Acad. Sci. USA
  Andere : Proc. Acad. Sci. U.S.A.
  Kurztitel : PNAS
Genre der Quelle: Zeitschrift
 Urheber:
Affiliations:
Ort, Verlag, Ausgabe: Washington, D.C. : National Academy of Sciences
Seiten: - Band / Heft: 100 (4) Artikelnummer: - Start- / Endseite: 1661 - 1666 Identifikator: ISSN: 0027-8424
CoNE: https://pure.mpg.de/cone/journals/resource/954925427230