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  Delineating the Transcriptional Mechanisms in Immunity behind Allergy and Asthma: Milestones and Challenges Ahead

Cauchy, P. (2017). Delineating the Transcriptional Mechanisms in Immunity behind Allergy and Asthma: Milestones and Challenges Ahead. International Journal of Allergy & Asthma, 1-15. doi:10.29011/IJAA-101.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0000-C15D-E Version Permalink: http://hdl.handle.net/21.11116/0000-0001-5CCF-0
Genre: Journal Article

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 Creators:
Cauchy, Pierre1, Author              
Affiliations:
1Department of Cellular and Molecular Immunology, Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society, ou_2243641              

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 Abstract: Allergy and asthma have roots in imbalances in immune cell homeostasis, namely a shift towards T-helper 2 (T)h2)-driven increases of Immunoglobulin E (IgE) immunity. Here, we describe the transcriptional processes that lead to the emergence of the immunological actors of allergy and asthma, i.e. Th2, type 2 Innate Lymphoid Cells (ILC2), mast, IgE plasma and regulatory T-cells (reg), as well as to the advent of imbalances towards Th2 responses in pathological cases. We review in detail the latest advance in terms of genome-wide characterisation of the transcriptional landscapes of the protagonists of allergy and asthma, both in norma and pathological contexts if available, as well as a summary of current clinical approaches and discuss the requirement for further functional-based genome-wide characterisation of mechanisms that can lead to the attenuation of these conditions.

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Language(s): eng - English
 Dates: 2017-06-27
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.29011/IJAA-101
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Title: International Journal of Allergy & Asthma
Source Genre: Journal
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Publ. Info: Gavin Publishers
Pages: - Volume / Issue: - Sequence Number: - Start / End Page: 1 - 15 Identifier: -