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  Effect of repeated lipopolysaccharide administration on tissue cytokine expression and hypothalamic-pituitary-adrenal axis activity in rats

Grinevich, V., Ma, X.-M., Herman, J. P., Jezova, D., Akmayev, I. G., & Aguilera, G. (2001). Effect of repeated lipopolysaccharide administration on tissue cytokine expression and hypothalamic-pituitary-adrenal axis activity in rats. Journal of Neuroendocrinology, 13(8), 711-723. doi:10.1046/j.1365-2826.2001.00684.x.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0000-3E6C-3 Version Permalink: http://hdl.handle.net/21.11116/0000-0000-3E70-D
Genre: Journal Article

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JNeuroendocrinol_13_2001_711.pdf (Any fulltext), 354KB
 
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 Creators:
Grinevich, Valery1, 2, Author              
Ma, Xin-Ming, Author
Herman, J. P., Author
Jezova, D., Author
Akmayev, Ildar G., Author
Aguilera, Greti, Author
Affiliations:
1Department of Molecular Neurobiology, Max Planck Institute for Medical Research, Max Planck Society, ou_1497704              
2Valery Grinevich Group, Max Planck Institute for Medical Research, Max Planck Society, ou_1497746              

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Free keywords: corticotropin releasing hormone; vasopressin; glucocorticoid receptors; cytokines; lipopolysaccharide
 Abstract: The effects of chronic immune challenge on cytokine expression and hypothalamic-pituitary-adrenal axis (HPA) axis responses to stress were studied in Wistar rats after administration of increasing doses of lipopolysaccharide (LPS). Repeated LPS (R-LPS) decreased body weight and increased adrenal weight and pituitary pro-opiomelanocortin mRNA levels. LPS injection increased plasma adrenocorticotropic hormone (ACTH) and corticosterone but the effect was attenuated in R-LPS. Plasma corticosterone but not ACTH responses to restraint were also reduced in R-LPS. Basal and restraint-stimulated corticotropin releasing hormone (CRH) mRNA levels were lower in R-LPS, but responses to a new LPS injection were similar to controls. In contrast, type 1 CRH receptor (CRH-R1) mRNA responses to both LPS and restraint were blunted in R-LPS. Vasopressin mRNA levels in parvocellular neurones were higher in R-LPS, and increased further after restraint but not after a new LPS injection. Glucocorticoid receptor (GR) levels in the paraventricular nucleus (PVN) increased after a single LPS or R-LPS (24 h after the last injection) but declined after a new injection in R-LPS. Interleukin (IL)-1beta and IL-6 mRNAs increased in the pituitary, spleen and circumventricular organs after single or R-LPS, suggesting that cytokines may contribute to the activation of the HPA axis though pathways from the circumventricular organs as well as paracrine effects in the pituitary. The data show that (i) adaptation of the HPA axis during repeated LPS injection involves increases in vasopressin : CRH expression ratios in parvocellular neurones; (ii) that hypothalamic CRH and vasopressin responses to acute stimulation are independent of CRH-R1 expression in the PVN; and (iii) there is a dissociation between pituitary and adrenal responses to acute stress suggesting a decrease of adrenal sensitivity to ACTH.

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Language(s): eng - English
 Dates: 20012001-04-302001-12-212001-08
 Publication Status: Published in print
 Pages: 13
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Degree: -

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Title: Journal of Neuroendocrinology
  Other : J. Neuroendocrinol.
Source Genre: Journal
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Publ. Info: Eynsham, Oxon, UK : Oxford University Press
Pages: - Volume / Issue: 13 (8) Sequence Number: - Start / End Page: 711 - 723 Identifier: ISSN: 0953-8194
CoNE: https://pure.mpg.de/cone/journals/resource/954925575990