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  SNX3 regulates endosomal function through its PX-domain-mediated interaction with PtdIns(3)P

Xu, Y., Horstmann, H., Seet, L., Wong, S. H., & Hong, W. (2001). SNX3 regulates endosomal function through its PX-domain-mediated interaction with PtdIns(3)P. Nature Cell Biology, 3, 658-666. doi:10.1038/35083051.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0000-3E76-7 Version Permalink: http://hdl.handle.net/21.11116/0000-0000-3E77-6
Genre: Journal Article

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NatCellBiol_3_2001_658.pdf (Any fulltext), 5MB
 
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 Creators:
Xu, Yue, Author
Horstmann, Heinz1, 2, 3, 4, Author              
Seet, Lifong, Author
Wong, Siew Heng, Author
Hong, Wanjin, Author
Affiliations:
1Synaptic Transmission MNTB, Max Planck Institute for Medical Research, Max Planck Society, ou_1497745              
2Department of Biomedical Optics, Max Planck Institute for Medical Research, Max Planck Society, ou_1497699              
3Synaptic Transmission, Max Planck Institute for Medical Research, Max Planck Society, ou_1497744              
4Department of Cell Physiology, Max Planck Institute for Medical Research, Max Planck Society, ou_1497701              

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 Abstract: The sorting nexin (SNX) protein family is implicated in regulating membrane traffic, but the mechanism is still unknown. We show that SNX3 is associated with the early endosome through a novel motif (PX domain) capable of interaction with phosphatidylinositol-3-phosphate (PtdIns(3)P). Overexpression of SNX3 alters endosomal morphology and delays transport to the lysosome. Transport from the early to the recycling endosome is affected upon microinjection of SNX3 antibodies. Our results highlight a novel mechanism by which SNX proteins regulate traffic and uncover a novel class of effectors for PtdIns(3)P.

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Language(s): eng - English
 Dates: 2001-05-042000-10-062001-05-222001-06-082001-07
 Publication Status: Published in print
 Pages: 9
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
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Title: Nature Cell Biology
  Other : 'Nat. Cell Biol.'
Source Genre: Journal
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Publ. Info: London : Macmillan Magazines Ltd.
Pages: - Volume / Issue: 3 Sequence Number: - Start / End Page: 658 - 666 Identifier: ISSN: 1465-7392
CoNE: https://pure.mpg.de/cone/journals/resource/954925625310