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  Inflammatory mediators potentiate ATP-gated channels through the P2X(3) subunit

Paukert, M., Osteroth, R., Geisler, H., Brändle, U., Glowatzki, E., Ruppersberg, J. P., et al. (2001). Inflammatory mediators potentiate ATP-gated channels through the P2X(3) subunit. The Journal of Biological Chemistry, 276(24), 21077-21082. doi:10.1074/jbc.M101465200.

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JBiolChem_276_2001_21077.pdf (Any fulltext), 261KB
 
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 Creators:
Paukert, Marti, Author
Osteroth, Ralph, Author
Geisler, Hyun−Soon, Author
Brändle, Uwe, Author
Glowatzki, Elisabeth, Author
Ruppersberg, J. Peter1, Author              
Gründer, Stefan, Author
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1Department of Cell Physiology, Max Planck Institute for Medical Research, Max Planck Society, ou_1497701              

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 Abstract: The P2X(3) receptor is an ATP-gated ion channel predominantly expressed in nociceptive neurons from the dorsal root ganglion. P2X(3) receptor channels are highly expressed in sensory neurons and probably contribute to the sensation of pain. Kinetics of P2X(3) currents are characterized by rapid desensitization (<100 ms) and slow recovery (>20 s). Thus, any mechanism modulating rate of desensitization and/or recovery may have profound effect on susceptibility of nociceptive neurons expressing P2X(3) to ATP. Here we show that currents mediated by P2X(3) receptor channels and the heteromeric channel P2X(2/3) composed of P2X(2) and P2X(3) subunits are potentiated by the neuropeptides substance P and bradykinin, which are known to modulate pain perception. The effect is mediated by the respective neuropeptide receptors, can be mimicked by phorbol ester and blocked by inhibitors of protein kinases. Together with data from site-directed mutagenesis our results suggest that inflammatory mediators sensitize nociceptors through phosphorylation of P2X(3) and P2X(2/3) ion channels or associated proteins.

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Language(s): eng - English
 Dates: 2001-02-152001-03-202001-03-222001-06-15
 Publication Status: Published in print
 Pages: 6
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
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Title: The Journal of Biological Chemistry
  Other : JBC
Source Genre: Journal
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Publ. Info: Baltimore, etc. : American Society for Biochemistry and Molecular Biology [etc.]
Pages: - Volume / Issue: 276 (24) Sequence Number: - Start / End Page: 21077 - 21082 Identifier: ISSN: 0021-9258
CoNE: https://pure.mpg.de/cone/journals/resource/954925410826_1