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  A dendrodendritic reciprocal synapse provides a recurrent excitatory connection in the olfactory bulb

Didier, A., Carleton, A., Bjaalie, J. G., Vincent, J., Ottersen, O. P., Storm−Mathisen, J., et al. (2001). A dendrodendritic reciprocal synapse provides a recurrent excitatory connection in the olfactory bulb. Proceedings of the National Academy of Sciences of the United States of America, 98(11), 6441-6446. doi:10.1073/pnas.101126398.

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Item Permalink: https://hdl.handle.net/21.11116/0000-0000-3EB6-E Version Permalink: https://hdl.handle.net/21.11116/0000-0000-3EB7-D
Genre: Journal Article

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PNAS_98_2001_6441.pdf (Any fulltext), 456KB
 
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 Creators:
Didier, Anne, Author
Carleton, Alan1, 2, Author           
Bjaalie, Jan G., Author
Vincent, Jean−Didier, Author
Ottersen, Ole Petter, Author
Storm−Mathisen, Jon, Author
Lledo, Pierre−Marie, Author
Affiliations:
1Olfaction Web, Max Planck Institute for Medical Research, Max Planck Society, ou_1497733              
2Department of Cell Physiology, Max Planck Institute for Medical Research, Max Planck Society, ou_1497701              

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 Abstract: Neuronal synchronization in the olfactory bulb has been proposed to arise from a diffuse action of glutamate released from mitral cells (MC, olfactory bulb relay neurons). According to this hypothesis, glutamate spills over from dendrodendritic synapses formed between MC and granule cells (GC, olfactory bulb interneurons) to activate neighboring MC. The excitation of MC is balanced by a strong inhibition from GC. Here we show that MC excitation is caused by glutamate released from bulbar interneurons located in the GC layer. These reciprocal synapses depend on an unusual, 2-amino-5-phosphonovaleric acid-resistant, N-methyl-d-aspartate receptor. This type of feedback excitation onto relay neurons may strengthen the original sensory input signal and further extend the function of the dendritic microcircuit within the main olfactory bulb.

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Language(s): eng - English
 Dates: 2001-01-242001-05-22
 Publication Status: Issued
 Pages: 6
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1073/pnas.101126398
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Title: Proceedings of the National Academy of Sciences of the United States of America
  Other : Proceedings of the National Academy of Sciences of the USA
  Other : Proc. Acad. Sci. USA
  Other : Proc. Acad. Sci. U.S.A.
  Abbreviation : PNAS
Source Genre: Journal
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Publ. Info: Washington, D.C. : National Academy of Sciences
Pages: - Volume / Issue: 98 (11) Sequence Number: - Start / End Page: 6441 - 6446 Identifier: ISSN: 0027-8424
CoNE: https://pure.mpg.de/cone/journals/resource/954925427230