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  γ-Aminobutyric acidB autoreceptors in substantia nigra and neostriatum of the weaver mutant mouse

Radnikow, G., Titz, S., Mades, S., Bäurle, J., & Misgeld, U. (2001). γ-Aminobutyric acidB autoreceptors in substantia nigra and neostriatum of the weaver mutant mouse. Neuroscience Letters, 299(1-2), 81-84. doi:10.1016/S0304-3940(01)01496-3.

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NeurosciLett_299_2001_81.pdf (Any fulltext), 194KB
 
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 Creators:
Radnikow, Gabriele1, 2, Author           
Titz, Stefan, Author
Mades, Sandra, Author
Bäurle, Jörg, Author
Misgeld, Ulrich, Author
Affiliations:
1Cortical Circuits, Max Planck Institute for Medical Research, Max Planck Society, ou_1497694              
2Department of Cell Physiology, Max Planck Institute for Medical Research, Max Planck Society, ou_1497701              

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Free keywords: Kir3.2; G-protein-activated K+ currents; Presynaptic inhibition; R-baclofen; Neostriatum
 Abstract: The weaver mutation causes cell loss in the center of the substantia nigra, pars compacta. We compared the depression of γ-aminobutyric acid (GABA)A synaptic currents by the GABAB agonist R-baclofen in pars compacta neurons of weaver mice which were largely spared from cell degeneration and of wild-type mice. In weaver neurons the suppression of GABAA synaptic currents by R-baclofen was reduced compared to wild-type neurons. The EC50 of R-baclofen was 6.3 times higher in weaver than in wild-type mice. In the neostriatum, which is not a target of the mutation, such a difference did not exist. We conclude that in the pars compacta the weaver mutation leads to a reduced presynaptic autoinhibition through GABAB receptors which may promote survival of a subset of weaver neurons in the pars compacta.

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Language(s): eng - English
 Dates: 2000-12-152000-10-252000-12-152001-02-062001-02-16
 Publication Status: Published in print
 Pages: 4
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1016/S0304-3940(01)01496-3
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Title: Neuroscience Letters
Source Genre: Journal
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Publ. Info: Amsterdam : Elsevier
Pages: - Volume / Issue: 299 (1-2) Sequence Number: - Start / End Page: 81 - 84 Identifier: ISSN: 0304-3940
CoNE: https://pure.mpg.de/cone/journals/resource/954925512448