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  [Activity of vasopressin neurons in the human supraoptic nucleus: estrogen inhibitory effect]

Ishunina, T. A., Dolzhikov, A. A., & Grinevich, V. (2001). [Activity of vasopressin neurons in the human supraoptic nucleus: estrogen inhibitory effect]. Adv. Physiol. Sci., 32(1), 48-59. Retrieved from https://www.ncbi.nlm.nih.gov/pubmed/11234435.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0000-3FB4-F Version Permalink: http://hdl.handle.net/21.11116/0000-0000-3FB5-E
Genre: Journal Article
Alternative Title : [Article in Russian]

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 Creators:
Ishunina, T. A., Author
Dolzhikov, A. A., Author
Grinevich, Valery1, 2, Author              
Affiliations:
1Department of Molecular Neurobiology, Max Planck Institute for Medical Research, Max Planck Society, ou_1497704              
2Valery Grinevich Group, Max Planck Institute for Medical Research, Max Planck Society, ou_1497746              

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 Abstract: Activity of magnocellular vasopressin (VP) neurons in the human hypothalamus is sex- and age-dependent as judged from the size of the Golgi apparatus, neuronal size and VP mRNA levels. These parameters are significantly higher in young (< or = 50 years old) men than in young women and are markedly increased in postmenopausal women compared to premenopausal women. This data suggest an inhibitory effect of estrogens on metabolic activity of VP neurons in the human supraoptic nucleus (2SON), which is likely to be mediated via estrogen receptor (ER) beta. Estrogens were shown to mediate their inhibitory effect via ER beta. It is expressed to a much higher degree in the SON of young women than in other groups, whereas estrogen receptor alpha, that mediates stimulatory effects of estrogens, is present in a small proportion of SON neurons. In addition, estrogens inhibit p75 neurotrophin receptor expression in VP cells. In conclusion, we discuss the inhibitory role of estrogens in functional activity of human VP neurons, which is most probably mediated directly via ER beta and indirectly by p75 neurotrophin receptor.

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Language(s): eng - English
 Dates: 2001-03
 Publication Status: Published in print
 Pages: 12
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Degree: -

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Title: Adv. Physiol. Sci.
  Alternative Title : Adv. Physiol. Sci.
Source Genre: Journal
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Publ. Info: Moskva : Uspechi fiziologiceskich nauk
Pages: - Volume / Issue: 32 (1) Sequence Number: - Start / End Page: 48 - 59 Identifier: ISSN: 0301-1798