English
 
Help Privacy Policy Disclaimer
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
  In vivo dendritic calcium dynamics in deep-layer cortical pyramidal neurons

Helmchen, F., Svoboda, K., Denk, W., & Tank, D. W. (1999). In vivo dendritic calcium dynamics in deep-layer cortical pyramidal neurons. Nature Neuroscience, 2(11), 989-996. doi:10.1038/14788.

Item is

Basic

show hide
Genre: Journal Article

Files

show Files
hide Files
:
NatNeurosci_2_1999_989.pdf (Any fulltext), 849KB
 
File Permalink:
-
Name:
NatNeurosci_2_1999_989.pdf
Description:
-
OA-Status:
Visibility:
Restricted (Max Planck Institute for Medical Research, MHMF; )
MIME-Type / Checksum:
application/pdf
Technical Metadata:
Copyright Date:
-
Copyright Info:
-
License:
-

Locators

show
hide
Description:
-
OA-Status:
Locator:
https://doi.org/10.1038/14788 (Any fulltext)
Description:
-
OA-Status:

Creators

show
hide
 Creators:
Helmchen, Fritjof1, 2, 3, Author           
Svoboda, Karel, Author
Denk, Winfried4, Author           
Tank, David W., Author
Affiliations:
1Department of Cell Physiology, Max Planck Institute for Medical Research, Max Planck Society, ou_1497701              
2In Vivo Microscopy of Cortical Dynamics, Max Planck Institute for Medical Research, Max Planck Society, ou_1497716              
3Cortical Two Photon Imaging, Max Planck Institute for Medical Research, Max Planck Society, ou_1497695              
4Department of Biomedical Optics, Max Planck Institute for Medical Research, Max Planck Society, ou_1497699              

Content

show
hide
Free keywords: -
 Abstract: Dendritic Ca2+ action potentials in neocortical pyramidal neurons have been characterized in brain slices, but their presence and role in the intact neocortex remain unclear. Here we used two-photon microscopy to demonstrate Ca2+ electrogenesis in apical dendrites of deep-layer pyramidal neurons of rat barrel cortex in vivo. During whisker stimulation, complex spikes recorded intracellularly from distal dendrites and sharp waves in the electrocorticogram were accompanied by large dendritic [Ca2+ ] transients; these also occurred during bursts of action potentials recorded from somata of identified layer 5 neurons. The amplitude of the [Ca 2+] transients was largest proximal to the main bifurcation, where sodium action potentials produced little Ca2+ influx. In some cases, synaptic stimulation evoked [Ca2+] transients without a concomitant action potential burst, suggesting variable coupling between dendrite and soma.

Details

show
hide
Language(s): eng - English
 Dates: 1999-05-241999-09-071999-11-011999-11-01
 Publication Status: Published in print
 Pages: 8
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: Nature Neuroscience
  Other : Nat. Neurosci.
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: New York, NY : Nature America Inc.
Pages: - Volume / Issue: 2 (11) Sequence Number: - Start / End Page: 989 - 996 Identifier: ISSN: 1097-6256
CoNE: https://pure.mpg.de/cone/journals/resource/954925610931