English
 
User Manual Privacy Policy Disclaimer Contact us
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
  [The hierarchical relationships between the organs of the hypothalamo-hypophyseal-adrenal system (HHAS) in inflammation].

Grinevich, V., Poskrebysheva, E. A., Savelov, N. A., Abramova, N. A., & Akmayev, I. G. (1999). [The hierarchical relationships between the organs of the hypothalamo-hypophyseal-adrenal system (HHAS) in inflammation]. Adv. Physiol. Sci., 30(4), 50-66. Retrieved from http://www.ncbi.nlm.nih.gov/pubmed/10612188.

Item is

Basic

show hide
Item Permalink: http://hdl.handle.net/21.11116/0000-0000-4076-3 Version Permalink: http://hdl.handle.net/21.11116/0000-0000-4077-2
Genre: Journal Article
Alternative Title : [Article in Russian]

Files

show Files

Locators

show

Creators

show
hide
 Creators:
Grinevich, Valery1, 2, Author              
Poskrebysheva, E. A., Author
Savelov, N. A., Author
Abramova, N. A., Author
Akmayev, Ildar G., Author
Affiliations:
1Department of Molecular Neurobiology, Max Planck Institute for Medical Research, Max Planck Society, ou_1497704              
2Valery Grinevich Group, Max Planck Institute for Medical Research, Max Planck Society, ou_1497746              

Content

show
hide
Free keywords: -
 Abstract: The HPA axis is the major system of adaptation to the action of different stressors, including inflammatory agents. The glucocorticoids, the end product of HPA axis prevent the extension of inflammation. In this article we discuss the classic direct and feedback loops in the HPA axis during acute bacterial inflammation. On the basis of literary and own findings we put forward a speculation that different systemic cytokines released one by one during inflammation induce the appearance of new functional relations between the organs of HPA axis. Because of cytokines are involved in the modulation of hormonal sensitivity in the HPA axis the serious modification of direct as well as feedback relations is postulated. On the other hand cytokines and immune cells induce autocrine and paracrine production of cytokines in the HPA axis, that result in autonomization of pituitary and adrenals functions. So, the acute inflammation factors could be seen as "short-time" functional dominants of HPA axis functioning.

Details

show
hide
Language(s): eng - English
 Dates: 1999-12
 Publication Status: Published in print
 Pages: 17
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: Adv. Physiol. Sci.
  Alternative Title : Adv. Physiol. Sci.
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: -
Pages: - Volume / Issue: 30 (4) Sequence Number: - Start / End Page: 50 - 66 Identifier: -