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  Role of an A-type K+ conductance in the back-propagation of action potentials in the dendrites of hippocampal pyramidal neurons

Migliore, M., Hoffman, D. A., Magee, J. C., & Johnston, D. (1999). Role of an A-type K+ conductance in the back-propagation of action potentials in the dendrites of hippocampal pyramidal neurons. Journal of Computational Neuroscience, 7: 231549, pp. 5-15. doi:10.1023/A:1008906225285.

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JComputNeurosci_7_1999_5.pdf (Any fulltext), 119KB
 
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 Creators:
Migliore, Michele, Author
Hoffman, Dax A.1, 2, Author           
Magee, Jeffrey C., Author
Johnston, Daniel, Author
Affiliations:
1Department of Cell Physiology, Max Planck Institute for Medical Research, Max Planck Society, ou_1497701              
2Synaptic Plasticity and Behaviour, Max Planck Institute for Medical Research, Max Planck Society, ou_1497743              

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Free keywords: computational model; action potential; back propagation; KA conductance; associative interactions
 Abstract: Action potentials elicited in the axon actively back-propagate into the dendritic tree. During this process their amplitudes can be modulated by internal and external factors. We used a compartmental model of a hippocampal CA1 pyramidal neuron to illustrate how this modulation could depend on (1) the properties of an A-type K+ conductance that is expressed at high density in hippocampal dendrites and (2) the relative timing of synaptic activation. The simulations suggest that the time relationship between pre- and postsynaptic activity could help regulate the amplitude of back-propagating action potentials, especially in the distal portion of the dendritic tree.

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Language(s): eng - English
 Dates: 1999-07
 Publication Status: Published in print
 Pages: 11
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Degree: -

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Title: Journal of Computational Neuroscience
Source Genre: Journal
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Publ. Info: Boston : Kluwer Academic Publishers
Pages: - Volume / Issue: 7 Sequence Number: 231549 Start / End Page: 5 - 15 Identifier: ISSN: 0929-5313
CoNE: https://pure.mpg.de/cone/journals/resource/954925568787