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  Stable hydrolysis-resistant synthetic Polyribosylribitolphosphate derivates as vaccines against Haemophilus influenzae type b
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Item Permalink: http://hdl.handle.net/21.11116/0000-0000-740E-F Version Permalink: http://hdl.handle.net/21.11116/0000-0000-7410-B
Genre: Patent

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 Creators:
Seeberger, Peter H.1, Author              
Affiliations:
1Peter H. Seeberger, Biomolekulare Systeme, Max Planck Institute of Colloids and Interfaces, Max Planck Society, ou_2040285              

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 Abstract: The present invention provides a stable synthetic saccharide of Hib polyribosylribitol- phosphate (PRP) derivative and conjugate thereof. Said saccharide, said conjugate and pharmaceutical compositions thereof are hydrolysis-resistant, long-term stable and useful for the prevention and/or treatment of diseases associated with Haemophilus influenzae, and more specifically of diseases associated with Haemophilus influenzae type b, preferably diseases selected from meningitis, pneumonia, and epiglotitis. They have general formula (I): wherein A is formula (II) or formula (III); B is formula (IV); C is formula (V); D is formula (VI); E is formula (VII); F is formula (VIII) or formula (IX).

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 Dates: 2017-07-282018-02-01
 Publication Status: Published online
 Pages: -
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 Rev. Method: -
 Identifiers: Patent Application Nr.: WO2017EP69254
Patent Publication Nr.: WO2018020046
 Degree: -

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