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  Shifted dynamic interactions between subcortical nuclei and inferior frontal gyri during response preparation in persistent developmental stuttering

Metzger, F. L., Auer, T., Helms, G., Paulus, W., Frahm, J., Sommer, M., et al. (2018). Shifted dynamic interactions between subcortical nuclei and inferior frontal gyri during response preparation in persistent developmental stuttering. Brain Structure & Function, 223(1), 165-182. doi:10.1007/s00429-017-1476-1.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0000-62A4-8 Version Permalink: http://hdl.handle.net/21.11116/0000-0003-A524-A
Genre: Journal Article

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 Creators:
Metzger, F. Luise1, Author
Auer, Tibor2, 3, 4, Author
Helms, Gunther5, Author
Paulus, Walter1, Author
Frahm, Jens2, Author
Sommer, Martin1, Author
Neef, Nicole1, 6, Author              
Affiliations:
1Department of Clinical Neurophysiology, University Medical Center, Göttingen, Germany, ou_persistent22              
2Max Planck Institute for Biophysical Chemistry, Göttingen, Germany, ou_persistent22              
3MRC Cognition and Brain Sciences Unit, Cambridge, United Kingdom, ou_persistent22              
4Department of Psychology, Royal Holloway University of London, United Kingdom, ou_persistent22              
5Department of Medical Radiation Physics, Skånes University Hospital, Lund, Sweden, ou_persistent22              
6Department Neuropsychology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634551              

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Free keywords: Basal ganglia; Disinhibition; Inferior frontal gyrus; Persistent developmental stuttering; Response anticipation; Substantia nigra
 Abstract: Persistent developmental stuttering is associated with basal ganglia dysfunction or dopamine dysregulation. Here, we studied whole-brain functional connectivity to test how basal ganglia structures coordinate and reorganize sensorimotor brain networks in stuttering. To this end, adults who stutter and fluent speakers (control participants) performed a response anticipation paradigm in the MRI scanner. The preparation of a manual Go/No-Go response reliably produced activity in the basal ganglia and thalamus and particularly in the substantia nigra. Strikingly, in adults who stutter, substantia nigra activity correlated positively with stuttering severity. Furthermore, functional connectivity analyses yielded altered task-related network formations in adults who stutter compared to fluent speakers. Specifically, in adults who stutter, the globus pallidus and the thalamus showed increased network synchronization with the inferior frontal gyrus. This implies dynamic shifts in the response preparation-related network organization through the basal ganglia in the context of a non-speech motor task in stuttering. Here we discuss current findings in the traditional framework of how D1 and D2 receptor activity shapes focused movement selection, thereby suggesting a disproportional involvement of the direct and the indirect pathway in stuttering.

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Language(s): eng - English
 Dates: 2017-07-242018-01
 Publication Status: Published in print
 Pages: -
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 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1007/s00429-017-1476-1
PMID: 28741037
PMC: PMC5772149
Other: Epub 2017
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Project name : -
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Funding program : -
Funding organization : Max Planck Society
Project name : -
Grant ID : -
Funding program : Dorothea Schlözer Fellowship Programme
Funding organization : University of Göttingen
Project name : -
Grant ID : NE 1841/1-1 ; SO 429/4-1
Funding program : -
Funding organization : Deutsche Forschungsgemeinschaft (DFG)
Project name : -
Grant ID : 01GQ0812
Funding program : -
Funding organization : German Federal Ministry for Education and Research (BMBF)
Project name : -
Grant ID : MC-A060-53114
Funding program : -
Funding organization : Medical Research Council (MRC)

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Title: Brain Structure & Function
  Abbreviation : Brain Struct Funct
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: Berlin : Springer
Pages: - Volume / Issue: 223 (1) Sequence Number: - Start / End Page: 165 - 182 Identifier: ISSN: 1863-2653
CoNE: https://pure.mpg.de/cone/journals/resource/1863-2653