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  Intelligence: shared genetic basis between Mendelian disorders and a polygenic trait

Franic, S., Groen-Blokhuis, M. M., Dolan, C. V., Kattenberg, M. V., Pool, R., Xiao, X., et al. (2015). Intelligence: shared genetic basis between Mendelian disorders and a polygenic trait. European journal of human genetics, 23(10), 1378-1383. doi:10.1038/ejhg.2015.3.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0000-C6DF-6 Version Permalink: http://hdl.handle.net/21.11116/0000-0000-C6E0-3
Genre: Journal Article

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 Creators:
Franic, S., Author
Groen-Blokhuis, M. M., Author
Dolan, C. V., Author
Kattenberg, M. V., Author
Pool, R., Author
Xiao, X., Author
Scheet, P. A., Author
Ehli, E. A., Author
Davies, G. E., Author
van der Sluis, S., Author
Abdellaoui, A., Author
Hansell, N. K., Author
Martin, N. G., Author
Hudziak, J. J., Author
van Beijsterveldt, C. E., Author
Swagerman, S. C., Author
Hulshoff Pol, H. E., Author
de Geus, E. J., Author
Bartels, M., Author
Ropers, H. H.1, Author              
Hottenga, J. J., AuthorBoomsma, D. I., Author more..
Affiliations:
1Emeritus Group of Human Molecular Genetics (Head: Hans-Hilger Ropers), Max Planck Institute for Molecular Genetics, Max Planck Society, ou_2385695              

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Free keywords: Adolescent Adult Child Child, Preschool Female Genetic Testing/methods Genome, Human/genetics Humans Infant Intelligence/*genetics Male Multifactorial Inheritance/*genetics Phenotype Polymorphism, Single Nucleotide/genetics Quantitative Trait Loci/genetics Quantitative Trait, Heritable
 Abstract: Multiple inquiries into the genetic etiology of human traits indicated an overlap between genes underlying monogenic disorders (eg, skeletal growth defects) and those affecting continuous variability of related quantitative traits (eg, height). Extending the idea of a shared genetic basis between a Mendelian disorder and a classic polygenic trait, we performed an association study to examine the effect of 43 genes implicated in autosomal recessive cognitive disorders on intelligence in an unselected Dutch population (N=1316). Using both single-nucleotide polymorphism (SNP)- and gene-based association testing, we detected an association between intelligence and the genes of interest, with genes ELP2, TMEM135, PRMT10, and RGS7 showing the strongest associations. This is a demonstration of the relevance of genes implicated in monogenic disorders of intelligence to normal-range intelligence, and a corroboration of the utility of employing knowledge on monogenic disorders in identifying the genetic variability underlying complex traits.

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Language(s): eng - English
 Dates: 2015-02-252015-10
 Publication Status: Published in print
 Pages: 6
 Publishing info: -
 Table of Contents: -
 Rev. Method: -
 Identifiers: DOI: 10.1038/ejhg.2015.3
ISSN: 1476-5438 (Electronic)1018-4813 (Print)
 Degree: -

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Title: European journal of human genetics
  Other : Eur. J. Hum. Genet.
Source Genre: Journal
 Creator(s):
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Publ. Info: Nature Publishing Group
Pages: - Volume / Issue: 23 (10) Sequence Number: - Start / End Page: 1378 - 1383 Identifier: ISSN: 1018-4813
CoNE: https://pure.mpg.de/cone/journals/resource/954925585277_1