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  Molecular dissection of colorectal cancer in pre-clinical models identifies biomarkers predicting sensitivity to EGFR inhibitors

Schütte, M., Risch, T., Abdavi Azar, N., Boehnke, K., Schumacher, D., Keil, M., et al. (2017). Molecular dissection of colorectal cancer in pre-clinical models identifies biomarkers predicting sensitivity to EGFR inhibitors. Nature Communications, 8: 8:14262. doi:10.1038/ncomms14262.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0000-78CF-1 Version Permalink: http://hdl.handle.net/21.11116/0000-0000-78D0-E
Genre: Journal Article

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 Creators:
Schütte, M., Author
Risch, T.1, Author              
Abdavi Azar, N.1, Author              
Boehnke, K., Author
Schumacher, D., Author
Keil, M., Author
Yildiriman, R., Author
Jandrasits, C.1, Author
Borodina, T., Author
Amstislavskiy, V.1, Author              
Worth, C. L.1, Author
Schweiger, C., Author
Liebs, S., Author
Lange, M., Author
Warnatz, H. J.1, Author              
Butcher, L. M., Author
Barrett, J. E., Author
Sultan, M.1, Author
Wierling, C., Author
Golob-Schwarzl, N., Author
Lax, S., AuthorUranitsch, S., AuthorBecker, M., AuthorWelte, Y., AuthorRegan, J. L., AuthorSilvestrov, M., AuthorKehler, I., AuthorFusi, A., AuthorKessler, T., AuthorHerwig, R.2, Author              Landegren, U., AuthorWienke, D., AuthorNilsson, M., AuthorVelasco, J. A., AuthorGarin-Chesa, P., AuthorReinhard, C., AuthorBeck, S., AuthorSchafer, R., AuthorRegenbrecht, C. R., AuthorHenderson, D., AuthorLange, B., AuthorHaybaeck, J., AuthorKeilholz, U., AuthorHoffmann, J., AuthorLehrach, H.3, 4, 5, Author              Yaspo, M. L.1, Author               more..
Affiliations:
1Gene Regulation and Systems Biology of Cancer (Marie-Laure Yaspo), Independent Junior Research Groups (OWL), Max Planck Institute for Molecular Genetics, Max Planck Society, ou_2117287              
2Bioinformatics (Ralf Herwig), Dept. of Computational Molecular Biology (Head: Martin Vingron), Max Planck Institute for Molecular Genetics, Max Planck Society, ou_2385701              
3Emeritus Group of Vertebrate Genomics (Head: Hans Lehrach), Max Planck Institute for Molecular Genetics, Max Planck Society, ou_2385697              
4Alacris Theranostics GmbH, Fabeckstr. 60-62, D-14195 Berlin, Germany, ou_persistent22              
5Dahlem Centre for Genome Research and Medical Systems Biology, Fabeckstr. 60-62, 14195 Berlin, Germany, ou_persistent22              

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 Abstract: Colorectal carcinoma represents a heterogeneous entity, with only a fraction of the tumours responding to available therapies, requiring a better molecular understanding of the disease in precision oncology. To address this challenge, the OncoTrack consortium recruited 106 CRC patients (stages I-IV) and developed a pre-clinical platform generating a compendium of drug sensitivity data totalling >4,000 assays testing 16 clinical drugs on patient-derived in vivo and in vitro models. This large biobank of 106 tumours, 35 organoids and 59 xenografts, with extensive omics data comparing donor tumours and derived models provides a resource for advancing our understanding of CRC. Models recapitulate many of the genetic and transcriptomic features of the donors, but defined less complex molecular sub-groups because of the loss of human stroma. Linking molecular profiles with drug sensitivity patterns identifies novel biomarkers, including a signature outperforming RAS/RAF mutations in predicting sensitivity to the EGFR inhibitor cetuximab.

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Language(s): eng - English
 Dates: 2017-02-102017
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: -
 Identifiers: DOI: 10.1038/ncomms14262
ISSN: 2041-1723 (Electronic)
 Degree: -

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Title: Nature Communications
  Abbreviation : Nat. Commun.
Source Genre: Journal
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Publ. Info: London : Nature Publishing Group
Pages: - Volume / Issue: 8 Sequence Number: 8:14262 Start / End Page: - Identifier: ISSN: 2041-1723
CoNE: /journals/resource/2041-1723