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  Non-viral cellular substrates for human immunodeficiency virus type 1 protease

Shoeman, R. L., Kesselmeier, C., Mothes, E., Höner, B., & Traub, P. (1991). Non-viral cellular substrates for human immunodeficiency virus type 1 protease. FEBS Letters, 278(2), 199-203. doi:10.1016/0014-5793(91)80116-K.

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FEBSLett_278_1991_199.pdf (beliebiger Volltext), 545KB
 
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 Urheber:
Shoeman, Robert L.1, 2, 3, Autor           
Kesselmeier, Cornelia, Autor
Mothes, Elfriede, Autor
Höner, Bernd, Autor
Traub, Peter, Autor
Affiliations:
1Coherent diffractive imaging, Max Planck Institute for Medical Research, Max Planck Society, ou_1497692              
2Department of Biomolecular Mechanisms, Max Planck Institute for Medical Research, Max Planck Society, ou_1497700              
3Analytical Protein Biochemistry, Max Planck Institute for Medical Research, Max Planck Society, ou_1497690              

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Schlagwörter: HIV-1 protease; Cytoskeletal protein: Initiation factor 2 (IF 2)
 Zusammenfassung: A computer search revealed 10 proteins with homology to the sequence we originally identified in vimentin as the site of cleavage by human immunodeficiency virus type 1 (HIV-1) protease. Of these 10 proteins (actin, alpha-actinin, spectrin, tropomyosins, vinculin, dystrophin, MAP-2, villin, TRK-1 and Ig mu-chain), we show that 4 of the first 5 were cleaved in vitro by this protease, as are MAP-1 and -2 [(1990) J. Gen. Virol. 71, 1985-1991]. In these proteins, cleavage is not restricted to a single motif, but occurs at many sites. However, cleavage is not random, since 9 other proteins including the cytoskeletal proteins filamin and band 4.1 are not cleaved in the in vitro assay. Thus, the ability of HIV-1 protease to cleave specific components of the cytoskeleton may be an important, although as yet unevaluated aspect of the life cycle of this retrovirus and/or may directly contribute to the pathogenesis observed during infection.

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Sprache(n): eng - English
 Datum: 1990-10-291990-11-302001-12-071991-01-28
 Publikationsstatus: Erschienen
 Seiten: 5
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 Art der Begutachtung: Expertenbegutachtung
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Titel: FEBS Letters
  Andere : FEBS Lett.
Genre der Quelle: Zeitschrift
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Ort, Verlag, Ausgabe: Amsterdam : Elsevier
Seiten: - Band / Heft: 278 (2) Artikelnummer: - Start- / Endseite: 199 - 203 Identifikator: ISSN: 0014-5793
CoNE: https://pure.mpg.de/cone/journals/resource/954925399501