English
 
User Manual Privacy Policy Disclaimer Contact us
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
  Cloning, pharmacological characteristics and expression pattern of the rat GABAA receptor α4 subunit

Wisden, W., Herb, A., Wieland, H., Keinänen, K., Lüddens, H., & Seeburg, P. H. (1991). Cloning, pharmacological characteristics and expression pattern of the rat GABAA receptor α4 subunit. FEBS Letters, 289(2), 227-230. doi:10.1016/0014-5793(91)81076-K.

Item is

Basic

show hide
Item Permalink: http://hdl.handle.net/21.11116/0000-0000-654F-7 Version Permalink: http://hdl.handle.net/21.11116/0000-0000-6550-4
Genre: Journal Article

Files

show Files
hide Files
:
FEBSLett_289_1991_227.pdf (Any fulltext), 498KB
 
File Permalink:
-
Name:
FEBSLett_289_1991_227.pdf
Description:
-
Visibility:
Restricted (Max Planck Institute for Medical Research, MHMF; )
MIME-Type / Checksum:
application/pdf
Technical Metadata:
Copyright Date:
-
Copyright Info:
-
License:
-

Locators

show
hide
Description:
-
Description:
-

Creators

show
hide
 Creators:
Wisden, William, Author
Herb, Anne1, Author              
Wieland, Heike1, Author              
Keinänen, Kari, Author
Lüddens, Hartmut, Author
Seeburg, Peter H.1, Author              
Affiliations:
1Department of Molecular Neurobiology, Max Planck Institute for Medical Research, Max Planck Society, ou_1497704              

Content

show
hide
Free keywords: GABAA ; Benzodiazepine receptor; In situ hybridization; Thalamus; α Subunit heterogeneity
 Abstract: A cDNA of rat brain encoding the GABAA receptor α4 subunit has been cloned. Recombinant receptors composed of α4, β2 and γ2 subunits bind with high affinity the GABA agonist [3H]muscimol and the benzodiazepine ‘alcohol antagonist’ [3H]Ro 15-4513, but fail to bind benzodiazepine agonists. The α4 subunit is expressed mainly in the thalamus, as assessed by in situ hybridization histochemistry, and may participate in a major population of thalamic GABAA receptors. The α4 mRNA is found at lower levels in cortex and caudate putamen, and is rare in cerebellum.

Details

show
hide
Language(s): eng - English
 Dates: 1991-07-042002-01-161991-09-09
 Publication Status: Published in print
 Pages: 4
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1016/0014-5793(91)81076-K
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: FEBS Letters
  Other : FEBS Lett.
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: Amsterdam : Elsevier
Pages: - Volume / Issue: 289 (2) Sequence Number: - Start / End Page: 227 - 230 Identifier: ISSN: 0014-5793
CoNE: https://pure.mpg.de/cone/journals/resource/954925399501