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  Yolk sac macrophage progenitors traffic to the embryo during defined stages of development

Stremmel, C., Schuchert, R., Wagner, F., Thaler, R., Weinberger, T., Pick, R., et al. (2018). Yolk sac macrophage progenitors traffic to the embryo during defined stages of development. Nature Communications, 9: 75. doi:10.1038/s41467-017-02492-2.

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© The Author(s) 2017. Open Access

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 Creators:
Stremmel, C.1, Author
Schuchert, R.1, Author
Wagner, F.1, Author
Thaler, R.1, Author
Weinberger, T.1, Author
Pick, R.1, Author
Mass, E.1, Author
Ishikawa-Ankerhold, H. C.1, Author
Margraf, A.1, Author
Hutter, S.1, Author
Vagnozzi, R.1, Author
Klapproth, S.2, Author              
Frampton, J.1, Author
Yona, S.1, Author
Scheiermann, C.1, Author
Molkentin, J. D.1, Author
Jeschke, U.1, Author
Moser, M.2, Author              
Sperandio, M.1, Author
Massberg, S.1, Author
Geissmann, F.1, AuthorSchulz, C.1, Author more..
Affiliations:
1external, ou_persistent22              
2Fässler, Reinhard / Molecular Medicine, Max Planck Institute of Biochemistry, Max Planck Society, ou_1565147              

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Free keywords: HEMATOPOIETIC STEM-CELLS; TISSUE-RESIDENT MACROPHAGES; MONONUCLEAR PHAGOCYTE SYSTEM; MYELOID CELLS; CIRCULATING MONOCYTES; AORTIC ENDOTHELIUM; MOUSE EMBRYO; FETAL LIVER; LANGERHANS CELLS; IN-VIVOScience & Technology - Other Topics;
 Abstract: Tissue macrophages in many adult organs originate from yolk sac (YS) progenitors, which invade the developing embryo and persist by means of local self-renewal. However, the route and characteristics of YS macrophage trafficking during embryogenesis are incompletely understood. Here we show the early migration dynamics of YS-derived macrophage progenitors in vivo using fate mapping and intravital microscopy. From embryonic day 8.5 (E8.5) CX(3)CR1+ pre-macrophages are present in the mouse YS where they rapidly proliferate and gain access to the bloodstream to migrate towards the embryo. Trafficking of pre-macrophages and their progenitors from the YS to tissues peaks around E10.5, dramatically decreases towards E12.5 and is no longer evident from E14.5 onwards. Thus, YS progenitors use the vascular system during a restricted time window of embryogenesis to invade the growing fetus. These findings close an important gap in our understanding of the development of the innate immune system.

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Language(s): eng - English
 Dates: 2018-01-08
 Publication Status: Published online
 Pages: 14
 Publishing info: -
 Table of Contents: -
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Title: Nature Communications
  Abbreviation : Nat. Commun.
Source Genre: Journal
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Publ. Info: London : Nature Publishing Group
Pages: - Volume / Issue: 9 Sequence Number: 75 Start / End Page: - Identifier: ISSN: 2041-1723
CoNE: https://pure.mpg.de/cone/journals/resource/2041-1723