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  Pathways of cellular proteostasis in aging and disease

Klaips, C. L., Jayaraj, G. G., & Hartl, F. U. (2018). Pathways of cellular proteostasis in aging and disease. The Journal of Cell Biology: JCB, 217(1), 51-63. doi:10.1083/jcb.201709072.

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51.full.pdf (Publisher version), 2MB
 
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© 2018 Klaips et al. http://www.rupress.org/terms/https://creativecommons.org/licenses/by-nc-sa/4.0/This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms/). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 International license, as described at https://creativecommons.org/licenses/by-nc-sa/4.0/).
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Klaips, Courtney L.1, Author              
Jayaraj, Gopal Gunanathan1, Author              
Hartl, F. Ulrich1, Author              
Affiliations:
1Hartl, Franz-Ulrich / Cellular Biochemistry, Max Planck Institute of Biochemistry, Max Planck Society, ou_1565152              

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Free keywords: PROTEIN-QUALITY CONTROL; HEAT-SHOCK PROTEINS; UBIQUITIN-PROTEASOME SYSTEM; INCLUSION-BODY FORMATION; AMYLOID-LIKE FIBRILS; MOLECULAR CHAPERONES; HSP70 CHAPERONES; CAENORHABDITIS-ELEGANS; HUNTINGTONS-DISEASE; ALZHEIMERS-DISEASECell Biology;
 Abstract: Ensuring cellular protein homeostasis, or proteostasis, requires precise control of protein synthesis, folding, conformational maintenance, and degradation. A complex and adaptive proteostasis network coordinates these processes with molecular chaperones of different classes and their regulators functioning as major players. This network serves to ensure that cells have the proteins they need while minimizing misfolding or aggregation events that are hallmarks of age-associated proteinopathies, including neurodegenerative disorders such as Alzheimer's and Parkinson's diseases. It is now clear that the capacity of cells to maintain proteostasis undergoes a decline during aging, rendering the organism susceptible to these pathologies. Here we discuss the major proteostasis pathways in light of recent research suggesting that their age-dependent failure can both contribute to and result from disease. We consider different strategies to modulate proteostasis capacity, which may help develop urgently needed therapies for neurodegeneration and other age-dependent pathologies.

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Language(s): eng - English
 Dates: 2017-11-102018-01-02
 Publication Status: Published in print
 Pages: 13
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: ISI: 000419133900009
DOI: 10.1083/jcb.201709072
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Title: The Journal of Cell Biology : JCB
  Other : J. Cell Biol.
Source Genre: Journal
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Publ. Info: New York, NY : Rockefeller Institute Press
Pages: - Volume / Issue: 217 (1) Sequence Number: - Start / End Page: 51 - 63 Identifier: ISSN: 0021-9525
CoNE: https://pure.mpg.de/cone/journals/resource/991042742946024