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  Glutamate-operated channels: developmentally early and mature forms arise by alternative splicing

Monyer, H., Seeburg, P. H., & Wisden, W. (1991). Glutamate-operated channels: developmentally early and mature forms arise by alternative splicing. Neuron, 6(5), 799-810. doi:10.1016/0896-6273(91)90176-Z.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0000-6E4B-2 Version Permalink: http://hdl.handle.net/21.11116/0000-0000-6E4C-1
Genre: Journal Article

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Neuron_6_1991_799.pdf (Any fulltext), 20MB
 
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 Creators:
Monyer, Hannah1, Author              
Seeburg, Peter H.1, Author              
Wisden, William, Author
Affiliations:
1Department of Molecular Neurobiology, Max Planck Institute for Medical Research, Max Planck Society, ou_1497704              

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 Abstract: The expression of two alternative splice variants, Flip and Flop, in mRNAs encoding the four AMPA-selective glutamate receptors (GluR-A, -B, -C, and -D) was studied in the developing brain by in situ hybridization. These receptors are expressed prominently before birth, and patterns of distribution for Flip versions remain largely invariant during postnatal brain development. In contrast, the Flop versions are expressed at low levels prior to postnatal day 8. Around this time, the expression of Flop mRNAs increases throughout the brain, reaching adult levels by postnatal day 14. Thus, receptors carrying the Flop module appear to participate in mature receptor forms

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Language(s): eng - English
 Dates: 1991-02-261990-12-121991-05
 Publication Status: Published in print
 Pages: 12
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 Rev. Type: Peer
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Title: Neuron
Source Genre: Journal
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Publ. Info: Cambridge, Mass. : Cell Press
Pages: - Volume / Issue: 6 (5) Sequence Number: - Start / End Page: 799 - 810 Identifier: ISSN: 0896-6273
CoNE: https://pure.mpg.de/cone/journals/resource/954925560565