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  Transmitter regulation of voltage-dependent K+ channels expressed in Xenopus oocytes

Kavanaugh, M. P., Christie, M. J., Osborne, P. B., Busch, A. E., Shen, K. Z., Wu, Y. N., et al. (1991). Transmitter regulation of voltage-dependent K+ channels expressed in Xenopus oocytes. Biochemical Journal, 277(3), 899-902. doi:10.1042/bj2770899.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0000-7327-3 Version Permalink: http://hdl.handle.net/21.11116/0000-0000-7328-2
Genre: Journal Article

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BiochemJ_277_1991_899.pdf (Any fulltext), 913KB
 
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 Creators:
Kavanaugh, M. P., Author
Christie, M. J., Author
Osborne, P. B., Author
Busch, A. E., Author
Shen, K. Z., Author
Wu, Y. N., Author
Seeburg, Peter H.1, Author              
Adelman, John P., Author
North, R. A., Author
Affiliations:
1Department of Molecular Neurobiology, Max Planck Institute for Medical Research, Max Planck Society, ou_1497704              

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 Abstract: Voltage-dependent K+ channels (RBK1, RBK2 and RGK5) were co-expressed in Xenopus oocytes with 5-hydroxytryptamine (5-HT2) receptors. K+ currents measured 2-4 days later were inhibited by 5-HT (100 nM-10 microM, 20-30 s application) by up to 90%. The effect of 5-HT was mimicked by intracellular injection of Ins(1,4,5)P3. Increasing the Ca2+ concentration at the inner surface of excised membrane patches did not decrease the K+ current.

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Language(s): eng - English
 Dates: 1991-06-031991-03-251991-06-071991-08-01
 Publication Status: Published in print
 Pages: 4
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 Table of Contents: -
 Rev. Method: Peer
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Title: Biochemical Journal
Source Genre: Journal
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Publ. Info: London : Published by Portland Press on behalf of the Biochemical Society.
Pages: - Volume / Issue: 277 (3) Sequence Number: - Start / End Page: 899 - 902 Identifier: ISSN: 0264-6021
CoNE: /journals/resource/110992357308158