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  Molecular cloning of a novel G protein-coupled receptor that may belong to the neuropeptide receptor family

Eva, C., Keinänen, K., Monyer, H., Seeburg, P. H., & Sprengel, R. (1990). Molecular cloning of a novel G protein-coupled receptor that may belong to the neuropeptide receptor family. FEBS Letters, 271(1-2), 81-84. doi:10.1016/0014-5793(90)80377-U.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0000-7353-1 Version Permalink: http://hdl.handle.net/21.11116/0000-0000-7354-0
Genre: Journal Article

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FEBSLett_271_1990_81.pdf (Any fulltext), 746KB
 
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 Creators:
Eva, Carola, Author
Keinänen, Kari, Author
Monyer, Hannah1, Author              
Seeburg, Peter H.1, Author              
Sprengel, Rolf1, 2, 3, Author              
Affiliations:
1Department of Molecular Neurobiology, Max Planck Institute for Medical Research, Max Planck Society, ou_1497704              
2Rolf Sprengel Group, Max Planck Institute for Medical Research, Max Planck Society, ou_1497741              
3Olfaction Web, Max Planck Institute for Medical Research, Max Planck Society, ou_1497733              

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Free keywords: G protein receptor; Tachykinin receptor; Neuropeptide receptor
 Abstract: A novel cDNA encoding a putative G protein-coupled receptor was isolated from a rat forebrain cDNA library by homology screening. Sequence comparison demonstrates that the encoded polypeptide containing seven transmembrane domains shows highest homology with tachykinin receptors, particularly in the transmembrane domains and the first intracellular loop. The mRNA for this new receptor seems specifically expressed in brain and is prominently localized in specific nuclei of the rat brain, including thalamus, cerebral cortex and hippocampus. We speculate that a neuropeptide may be the natural ligand of this novel G protein-coupled receptor.

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Language(s): eng - English
 Dates: 1990-08-012001-11-121990-10
 Publication Status: Published in print
 Pages: 4
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Degree: -

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Title: FEBS Letters
  Other : FEBS Lett.
Source Genre: Journal
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Publ. Info: Amsterdam : Elsevier
Pages: - Volume / Issue: 271 (1-2) Sequence Number: - Start / End Page: 81 - 84 Identifier: ISSN: 0014-5793
CoNE: https://pure.mpg.de/cone/journals/resource/954925399501