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  Effects of the tetronic acid derivatives AO33 (losigamone) and AO78 on epileptiform activity and on stimulus-induced calcium concentration changes in rat hippocampal slices

Köhr, G., & Heinemann, U. (1990). Effects of the tetronic acid derivatives AO33 (losigamone) and AO78 on epileptiform activity and on stimulus-induced calcium concentration changes in rat hippocampal slices. Epilepsy Research, 7(1), 49-58. doi:10.1016/0920-1211(90)90053-X.

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Datensatz-Permalink: https://hdl.handle.net/21.11116/0000-0000-7379-7 Versions-Permalink: https://hdl.handle.net/21.11116/0000-0000-737A-6
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EpilepRes_7_1990_49.pdf (beliebiger Volltext), 2MB
 
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https://www.sciencedirect.com/science/article/pii/092012119090053X/pdf?md5=483bd72b1d522f087e346e0cc3a74d60&pid=1-s2.0-092012119090053X-main.pdf (beliebiger Volltext)
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https://doi.org/10.1016/0920-1211(90)90053-X (beliebiger Volltext)
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 Urheber:
Köhr, Georg1, 2, 3, Autor           
Heinemann, Uwe, Autor
Affiliations:
1Department of Molecular Neurobiology, Max Planck Institute for Medical Research, Max Planck Society, ou_1497704              
2Directly responsible to the Managing Director, Max Planck Institute for Medical Research, Max Planck Society, ou_persistent22              
3Georg Köhr Group, Max Planck Institute for Medical Research, Max Planck Society, ou_1497714              

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Schlagwörter: Picrotoxin; Low magnesium; Low calcium; Anticonvulsant; Hippocampus; Tetronic acid derivatives; Losigamone (Rat)
 Zusammenfassung: The effects of members of a new class of anticonvulsants, the tetronic acid derivatives, were studied in 3 in vitro models of epileptogenesis in rat hippocampal slices; the picrotoxin, the low magnesium and the low calcium model. The effects of AO33 (losigamone) and AO78 on stimulus-induced decreases in extracellular calcium concentration were also investigated. In all 3 models of epileptogenesis, both drugs blocked spontaneous and reduced stimulus-induced epileptiform discharges dose dependently and reversibly. Stimulus-induced changes in [Ca2+]0 were markedly diminished by these agents. The fact that the tetronic acid derivatives block the low Ca seizure-like events which develop independently from chemical synaptic transmission suggests that these agents have non-synaptic or direct membrane actions with subsequently reduced cellular excitability

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Sprache(n): eng - English
 Datum: 1989-12-281990-04-232003-03-051990-10
 Publikationsstatus: Erschienen
 Seiten: 10
 Ort, Verlag, Ausgabe: -
 Inhaltsverzeichnis: -
 Art der Begutachtung: Expertenbegutachtung
 Identifikatoren: DOI: 10.1016/0920-1211(90)90053-X
URI: https://www.ncbi.nlm.nih.gov/pubmed/2292246
 Art des Abschluß: -

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Titel: Epilepsy Research
Genre der Quelle: Zeitschrift
 Urheber:
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Ort, Verlag, Ausgabe: Amsterdam : Elsevier
Seiten: - Band / Heft: 7 (1) Artikelnummer: - Start- / Endseite: 49 - 58 Identifikator: ISSN: 0920-1211
CoNE: https://pure.mpg.de/cone/journals/resource/954926240466