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  Effects of the tetronic acid derivatives AO33 (losigamone) and AO78 on epileptiform activity and on stimulus-induced calcium concentration changes in rat hippocampal slices

Köhr, G., & Heinemann, U. (1990). Effects of the tetronic acid derivatives AO33 (losigamone) and AO78 on epileptiform activity and on stimulus-induced calcium concentration changes in rat hippocampal slices. Epilepsy Research, 7(1), 49-58. doi:10.1016/0920-1211(90)90053-X.

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EpilepRes_7_1990_49.pdf (Any fulltext), 2MB
 
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 Creators:
Köhr, Georg1, 2, 3, Author              
Heinemann, Uwe, Author
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1Department of Molecular Neurobiology, Max Planck Institute for Medical Research, Max Planck Society, ou_1497704              
2Directly responsible to the Managing Director, Max Planck Institute for Medical Research, Max Planck Society, ou_persistent22              
3Georg Köhr Group, Max Planck Institute for Medical Research, Max Planck Society, ou_1497714              

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Free keywords: Picrotoxin; Low magnesium; Low calcium; Anticonvulsant; Hippocampus; Tetronic acid derivatives; Losigamone (Rat)
 Abstract: The effects of members of a new class of anticonvulsants, the tetronic acid derivatives, were studied in 3 in vitro models of epileptogenesis in rat hippocampal slices; the picrotoxin, the low magnesium and the low calcium model. The effects of AO33 (losigamone) and AO78 on stimulus-induced decreases in extracellular calcium concentration were also investigated. In all 3 models of epileptogenesis, both drugs blocked spontaneous and reduced stimulus-induced epileptiform discharges dose dependently and reversibly. Stimulus-induced changes in [Ca2+]0 were markedly diminished by these agents. The fact that the tetronic acid derivatives block the low Ca seizure-like events which develop independently from chemical synaptic transmission suggests that these agents have non-synaptic or direct membrane actions with subsequently reduced cellular excitability

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Language(s): eng - English
 Dates: 1989-12-281990-04-232003-03-051990-10
 Publication Status: Published in print
 Pages: 10
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Degree: -

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Title: Epilepsy Research
Source Genre: Journal
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Publ. Info: Amsterdam : Elsevier
Pages: - Volume / Issue: 7 (1) Sequence Number: - Start / End Page: 49 - 58 Identifier: ISSN: 0920-1211
CoNE: https://pure.mpg.de/cone/journals/resource/954926240466