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  Human immunodeficiency virus type 1 protease cleaves the intermediate filament proteins vimentin, desmin, and glial fibrillary acidic protein

Shoeman, R. L., Höner, B., Stoller, T. J., Kesselmeier, C., Miedel, M. C., Traub, P., et al. (1990). Human immunodeficiency virus type 1 protease cleaves the intermediate filament proteins vimentin, desmin, and glial fibrillary acidic protein. Proceedings of the National Academy of Sciences of the United States of America, 87(16), 6336-6340. doi:10.1073/pnas.87.16.6336.

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Datensatz-Permalink: https://hdl.handle.net/21.11116/0000-0000-738C-1 Versions-Permalink: https://hdl.handle.net/21.11116/0000-0000-738D-0
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PNAS_87_1990_6336.pdf (beliebiger Volltext), 2MB
 
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http://www.pnas.org/content/87/16/6336.full.pdf (beliebiger Volltext)
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 Urheber:
Shoeman, Robert L.1, 2, 3, Autor           
Höner, Bernd, Autor
Stoller, Timothy J., Autor
Kesselmeier, Cornelia, Autor
Miedel, May C., Autor
Traub, Peter, Autor
Graves, Mary C., Autor
Affiliations:
1Coherent diffractive imaging, Max Planck Institute for Medical Research, Max Planck Society, ou_1497692              
2Department of Biomolecular Mechanisms, Max Planck Institute for Medical Research, Max Planck Society, ou_1497700              
3Analytical Protein Biochemistry, Max Planck Institute for Medical Research, Max Planck Society, ou_1497690              

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 Zusammenfassung: The intermediate filament proteins vimentin, desmin, and glial fibrillary acidic protein are cleaved in vitro by human immunodeficiency virus type 1 protease (HIV-1 PR). Microsequencing showed that HIV-1 PR cleaved both human and murine vimentin between leucine-422 and arginine-423 within the sequence between positions 418 and 427, Ser-Ser-Leu-Asn-Leu/Arg-Glu-Thr-Asn-Leu (SSLNL/RETNL). Minor cleavages at other sites were also observed. Heat-denatured vimentin was cleaved by HIV-1 PR less efficiently than native vimentin. A decapeptide containing the sequence SSLN-LRETNL was also cleaved in vitro by HIV-1 PR as predicted. The presence of a charged residue (arginine) at the primary cleavage site distinguishes this from other known naturally occurring cleavage sites. Microinjection of HIV-1 PR into cultured human fibroblasts resulted in a 9-fold increase in the percentage of cells with an altered and abnormal distribution of vimentin intermediate filaments. Most commonly, the intermediate filaments collapsed into a clump with a juxtanuclear localization. These results support the possibility that intermediate filament proteins may serve as substrates within HIV-1-infected cells.

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Sprache(n): eng - English
 Datum: 1990-05-2919901990-08-15
 Publikationsstatus: Erschienen
 Seiten: 5
 Ort, Verlag, Ausgabe: -
 Inhaltsverzeichnis: -
 Art der Begutachtung: Expertenbegutachtung
 Identifikatoren: DOI: 10.1073/pnas.87.16.6336
URI: https://www.ncbi.nlm.nih.gov/pubmed/2201025
URI: https://www.ncbi.nlm.nih.gov/m/pubmed/2201025/
URI: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC54528/
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Titel: Proceedings of the National Academy of Sciences of the United States of America
  Andere : Proceedings of the National Academy of Sciences of the USA
  Andere : Proc. Acad. Sci. USA
  Andere : Proc. Acad. Sci. U.S.A.
  Kurztitel : PNAS
Genre der Quelle: Zeitschrift
 Urheber:
Affiliations:
Ort, Verlag, Ausgabe: Washington, D.C. : National Academy of Sciences
Seiten: - Band / Heft: 87 (16) Artikelnummer: - Start- / Endseite: 6336 - 6340 Identifikator: ISSN: 0027-8424
CoNE: https://pure.mpg.de/cone/journals/resource/954925427230