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  X-chromosome dosage as a modulator of pluripotency, signalling and differentiation?

Schulz, E. G. (2017). X-chromosome dosage as a modulator of pluripotency, signalling and differentiation? Philosophical Transactions of the Royal Society of London, Series B: Biological Sciences, 372(1733): pii: 20160366. doi:10.1098/rstb.2016.0366.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0000-74B6-0 Version Permalink: http://hdl.handle.net/21.11116/0000-0000-74B7-F
Genre: Journal Article

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 Creators:
Schulz, Edda G.1, Author              
Affiliations:
1Regulatory Networks in Stem Cells (Edda G. Schulz), Independent Junior Research Groups (OWL), Max Planck Institute for Molecular Genetics, Max Planck Society, ou_2117286              

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Free keywords: X-chromosome; development; embryonic stem cells; pluripotency; signalling pathways
 Abstract: Already during early embryogenesis, before sex-specific hormone production is initiated, sex differences in embryonic development have been observed in several mammalian species. Typically, female embryos develop more slowly than their male siblings. A similar phenotype has recently been described in differentiating murine embryonic stem cells, where a double dose of the X-chromosome halts differentiation until dosage-compensation has been achieved through X-chromosome inactivation. On the molecular level, several processes associated with early differentiation of embryonic stem cells have been found to be affected by X-chromosome dosage, such as the transcriptional state of the pluripotency network, the activity pattern of several signal transduction pathways and global levels of DNA-methylation. This review provides an overview of the sex differences described in embryonic stem cells from mice and discusses a series of X-linked genes that are associated with pluripotency, signalling and differentiation and their potential involvement in mediating the observed X-dosage-dependent effects.This article is part of the themed issue 'X-chromosome inactivation: a tribute to Mary Lyon'.

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Language(s): eng - English
 Dates: 2017-09-252017-11-05
 Publication Status: Published in print
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 Identifiers: DOI: 10.1098/rstb.2016.0366
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Title: Philosophical Transactions of the Royal Society of London, Series B: Biological Sciences
Source Genre: Journal
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Publ. Info: London : Royal Society
Pages: - Volume / Issue: 372 (1733) Sequence Number: pii: 20160366 Start / End Page: - Identifier: ISSN: 0962-8436
CoNE: /journals/resource/963017382021_1