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  A modified reading the mind in the eyes test predicts behavioral variant frontotemporal dementia better than executive function tests

Schroeter, M. L., Pawelke, S., Bisenius, S., Kynast, J., Schuemberg, K., Polyakova, M., et al. (2018). A modified reading the mind in the eyes test predicts behavioral variant frontotemporal dementia better than executive function tests. Frontiers in Aging Neuroscience, 10: 11. doi:10.3389/fnagi.2018.00011.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0000-7548-C Version Permalink: http://hdl.handle.net/21.11116/0000-0003-A2EA-E
Genre: Journal Article

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 Creators:
Schroeter, Matthias L.1, Author              
Pawelke, Sarah1, Author
Bisenius, Sandrine1, Author              
Kynast, Jana1, Author              
Schuemberg, Katharina1, Author
Polyakova, Maryna1, Author              
Anderl-Straub, Sarah2, Author
Danek, Adrian3, Author
Fassbender, Klaus4, Author
Jahn, Holger5, Author
Jessen, Frank6, Author
Kornhuber, Johannes7, Author
Lauer, Martin8, Author
Prudlo, Johannes9, Author
Schneider, Anja6, 10, Author
Uttner, Ingo2, Author
Thöne-Otto, Angelika I. T.1, Author              
Otto, Markus2, Author
Diehl-Schmid, Janina11, Author
FTLD Study Group Germany, Author              
Affiliations:
1Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634549              
2Department of Neurology, Ulm University, Germany, ou_persistent22              
3Department of Neurology, Ludwig Maximilians University Munich, Germany, ou_persistent22              
4Department of Neurology, Saarland University Homburg, Germany, ou_persistent22              
5Department of Psychiatry and Psychotherapy, University Medical Center Hamburg-Eppendorf, Germany, ou_persistent22              
6Department of Psychiatry and Psychotherapy, University Bonn, Germany, ou_persistent22              
7Department of Psychiatry and Psychotherapy, Friedrich Alexander University Erlangen, Germany, ou_persistent22              
8Department of Psychiatry, Psychosomatics and Psychotherapy, University Hospital Würzburg, Germany, ou_persistent22              
9Department of Neurology, University Medicine Rostock, Germany, ou_persistent22              
10Department of Psychiatry and Psychotherapy, Georg August University, Göttingen, Germany, ou_persistent22              
11Departments of Psychiatry and Psychotherapy, TU Munich, Germany, ou_persistent22              

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Free keywords: Behavioral variant frontotemporal dementia; Diagnostic criteria; Executive function; Social cognition; Theory of mind
 Abstract: Behavioral variant frontotemporal dementia (bvFTD) is characterized by deep alterations in behavior and personality. Although revised diagnostic criteria agree for executive dysfunction as most characteristic, impairments in social cognition are also suggested. The study aimed at identifying those neuropsychological and behavioral parameters best discriminating between bvFTD and healthy controls. Eighty six patients were diagnosed with possible or probable bvFTD according to Rascovsky et al. (2011) and compared with 43 healthy age-matched controls. Neuropsychological performance was assessed with a modified Reading the Mind in the Eyes Test (RMET), Stroop task, Trail Making Test (TMT), Hamasch-Five-Point Test (H5PT), and semantic and phonemic verbal fluency tasks. Behavior was assessed with the Apathy Evaluation Scale, Frontal Systems Behavioral Scale, and Bayer Activities of Daily Living Scale. Each test’s discriminatory power was investigated by Receiver Operating Characteristic curves calculating the area under the curve (AUC). bvFTD patients performed significantly worse than healthy controls in all neuropsychological tests. Discriminatory power (AUC) was highest in behavioral questionnaires, high in verbal fluency tasks and the RMET, and lower in executive function tests such as the Stroop task, TMT and H5PT. As fluency tasks depend on several cognitive functions, not only executive functions, results suggest that the RMET discriminated better between bvFTD and control subjects than other executive tests. Social cognition should be incorporated into diagnostic criteria for bvFTD in the future, such as in the International Classification of Diseases (ICD)-11, as already suggested in the Diagnostic and Statistical Manual for Mental Disorders (DSM)-5.

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Language(s): eng - English
 Dates: 2017-07-132018-01-102018-01-30
 Publication Status: Published online
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.3389/fnagi.2018.00011
PMID: 29441012
PMC: PMC5797534
Other: eCollection 2018
 Degree: -

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Project name : German Consortium for Frontotemporal Lobar Degeneration
Grant ID : 01GI1007A
Funding program : -
Funding organization : German Federal Ministry of Education and Research (BMBF)
Project name : -
Grant ID : -
Funding program : -
Funding organization : Max-Planck International Research Network on Aging (MaxNetAging)
Project name : -
Grant ID : -
Funding program : -
Funding organization : International Max Planck Research School on Neuroscience of Communication: Function, Structure, and Plasticity (IMPRS NeuroCom)
Project name : -
Grant ID : PDF-IRG-1307
Funding program : -
Funding organization : Parkinson’s Disease Foundation
Project name : -
Grant ID : 11362
Funding program : -
Funding organization : Michael J. Fox Foundation

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Title: Frontiers in Aging Neuroscience
  Abbreviation : Front Aging Neurosci
Source Genre: Journal
 Creator(s):
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Publ. Info: Lausanne : Frontiers Research Foundation
Pages: - Volume / Issue: 10 Sequence Number: 11 Start / End Page: - Identifier: ISSN: 1663-4365
CoNE: https://pure.mpg.de/cone/journals/resource/1663-4365