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  Functional segregation of the right inferior frontal gyrus: Evidence from coactivation-based parcellation

Hartwigsen, G., Neef, N., Camilleri, J., Margulies, D. S., & Eickhoff, S. B. (2019). Functional segregation of the right inferior frontal gyrus: Evidence from coactivation-based parcellation. Cerebral Cortex, 29(4), 1532-1546. doi:10.1093/cercor/bhy049.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0000-776B-3 Version Permalink: http://hdl.handle.net/21.11116/0000-0005-51FB-5
Genre: Journal Article

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 Creators:
Hartwigsen, Gesa1, Author              
Neef, Nicole1, Author              
Camilleri, Julia2, 3, Author
Margulies, Daniel S.4, Author
Eickhoff, Simon B.2, 3, Author
Affiliations:
1Department Neuropsychology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634551              
2Institute of Systems Neuroscience, University Hospital Düsseldorf, Germany , ou_persistent22              
3Institute of Neuroscience and Medicine, Research Center Jülich, Germany, ou_persistent22              
4Institut du Cerveau et de la Moelle épinière (ICM), Université Paris-Sorbonne, France, ou_persistent22              

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Free keywords: Meta-analysis; Functional connectivity; Functional decoding; Action; Social cognition
 Abstract: Previous studies helped unraveling the functional architecture of the human cerebral cortex. However, a comprehensive functional segregation of right lateral prefrontal cortex is missing. Here, we delineated cortical clusters in right area 44 and 45 based on their task-constrained whole-brain activation patterns across neuroimaging experiments obtained from a large database. We identified five clusters that differed with respect to their coactivation patterns, which were consistent with resting-state functional connectivity patterns of an independent dataset. Two clusters in the posterior inferior frontal gyrus (IFG) were functionally associated with action inhibition and execution, while two anterior clusters were related to reasoning and social cognitive processes. A fifth cluster was associated with spatial attention. Strikingly, the functional organization of the right IFG can thus be characterized by a posterior-to-anterior axis with action-related functions on the posterior and cognition-related functions on the anterior end. We observed further subdivisions along a dorsal-to-ventral axis in posterior IFG between action execution and inhibition, and in anterior IFG between reasoning and social cognition. The different clusters were integrated in distinct large-scale networks for various cognitive processes. These results provide evidence for a general organization of cognitive processes along axes spanning from more automatic to more complex cognitive processes.

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Language(s): eng - English
 Dates: 2018-02-132017-06-292018-02-142018-04-182019-04
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1093/cercor/bhy049
PMID: 29912435
Other: Epub ahead of print
 Degree: -

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Funding organization : Max Planck Society

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Title: Cerebral Cortex
Source Genre: Journal
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Publ. Info: New York, NY : Oxford University Press
Pages: - Volume / Issue: 29 (4) Sequence Number: - Start / End Page: 1532 - 1546 Identifier: ISSN: 1047-3211
CoNE: https://pure.mpg.de/cone/journals/resource/954925592440