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  Low episodic memory performance in cognitively normal elderly subjects is associated with increased posterior cingulate gray matter N-acetylaspartate: A 1H MRSI Study at 7 Teslas

Schreiner, S., Kirchner, T., Wyss, M., Van Bergen, J., Quevenco, F., Steiniger, S., et al. (2016). Low episodic memory performance in cognitively normal elderly subjects is associated with increased posterior cingulate gray matter N-acetylaspartate: A 1H MRSI Study at 7 Teslas. Neurobiology of Aging, 48, 195-203. doi:10.1016/j.neurobiolaging.2016.08.022.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0000-793F-3 Version Permalink: http://hdl.handle.net/21.11116/0000-0001-1EF8-7
Genre: Journal Article

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Schreiner, SJ, Author
Kirchner, T, Author
Wyss, M, Author
Van Bergen, JMG, Author
Quevenco, FC, Author
Steiniger, SC, Author
Griffith, EY, Author
Meier, I, Author
Michels, L, Author
Gietl, A, Author
Leh, SE, Author
Brickman, AM, Author
Hock, C, Author
Nitsch, RM, Author
Pruessmann, KP, Author
Henning, A1, 2, Author              
Unschuld, PG, Author
Affiliations:
1Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497794              
2Research Group MR Spectroscopy and Ultra-High Field Methodology, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_2528692              

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 Abstract: Low episodic memory performance characterizes elderly subjects at increased risk for Alzheimer's disease (AD) and may reflect neuronal dysfunction within the posterior cingulate cortex and precuneus region (PCP). To investigate a potential association between cerebral neuro-metabolism and low episodic memory in the absence of cognitive impairment, tissue specific magnetic resonance spectroscopic imaging (MRSI) at ultra-high field strength of 7 Tesla was used to investigate the PCP-region in a healthy elderly study population (n=30, age 70±5.7 years, Mini Mental State Examination 29.4±4.1). The Verbal Learning and Memory Test (VLMT) was administered as part of a neuropsychological battery for assessment of episodic memory performance. Significant differences between PCP-gray and white matter could be observed for glutamate-glutamine (p=0.001), choline (p=0.01) and myo-inositol (p=0.02). Low VLMT performance was associated with high N-acetylaspartate in PCP-gray matter (p=0.01), but not in PCP-white matter. Our data suggest that subtle decreases in episodic memory performance in the elderly may be associated with increased levels of NAA as a reflection of increased mitochondrial energy capacity in PCP-gray matter.

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 Dates: 2016-12
 Publication Status: Published in print
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 Identifiers: DOI: 10.1016/j.neurobiolaging.2016.08.022
BibTex Citekey: SchreinerKWVQSGMMGLBHNPHU2016
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Title: Neurobiology of Aging
Source Genre: Journal
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Pages: - Volume / Issue: 48 Sequence Number: - Start / End Page: 195 - 203 Identifier: -