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  High and ultra-high resolution metabolite mapping of the human brain using 1H FID MRSI at 9.4T

Nassirpour, S., Chang, P., & Henning, A. (2018). High and ultra-high resolution metabolite mapping of the human brain using 1H FID MRSI at 9.4T. NeuroImage, 168, 211-221. doi:10.1016/j.neuroimage.2016.12.065.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0000-794B-5 Version Permalink: http://hdl.handle.net/21.11116/0000-0001-8002-B
Genre: Journal Article

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Nassirpour, S1, 2, Author              
Chang, P1, 2, Author              
Henning, A1, 2, Author              
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1Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497794              
2Research Group MR Spectroscopy and Ultra-High Field Methodology, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_2528692              

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 Abstract: Magnetic resonance spectroscopic imaging (MRSI) is a promising technique for mapping the spatial distribution of multiple metabolites in the human brain. These metabolite maps can be used as a diagnostic tool to gain insight into several biochemical processes and diseases in the brain. In comparison to lower field strengths, MRSI at ultra-high field strengths benefits from a higher signal to noise ratio (SNR) as well as higher chemical shift dispersion, and hence spectral resolution. This study combines the benefits of an ultra-high field magnet with the advantages of an ultra-short TE and TR single-slice FID-MRSI sequence (such as negligible J-evolution and loss of SNR due to T2 relaxation effects) and presents the first metabolite maps acquired at 9.4 T in the healthy human brain at both high (voxel size of 97.6 µL) and ultra-high (voxel size of 24.4 µL) spatial resolutions in a scan time of 11 and 46 min respectively. In comparison to lower field strengths, more anatomically-detailed maps with higher SNR from a larger number of metabolites are shown. A total of 12 metabolites including glutamate (Glu), glutamine (Gln), N-acetyl-aspartyl-glutamate (NAAG), Gamma-aminobutyric acid (GABA) and glutathione (GSH) are reliably mapped. Comprehensive description of the methodology behind these maps is provided.

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 Dates: 2016-122018-03
 Publication Status: Published in print
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 Identifiers: DOI: 10.1016/j.neuroimage.2016.12.065
BibTex Citekey: NassirpourCH2016
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Title: NeuroImage
Source Genre: Journal
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Pages: - Volume / Issue: 168 Sequence Number: - Start / End Page: 211 - 221 Identifier: -