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  Near-Infrared Photoacoustic Imaging Probe Responsive to Calcium

Mishra, A., Jiang, Y., Roberts, S., Ntziachristos, V., & Westmeyer, G. (2016). Near-Infrared Photoacoustic Imaging Probe Responsive to Calcium. Analytical Chemistry, 88(22), 10785-10789. doi:10.1021/acs.analchem.6b03039.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0000-7955-9 Version Permalink: http://hdl.handle.net/21.11116/0000-0000-7956-8
Genre: Journal Article

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Mishra, A1, Author              
Jiang, Y2, 3, Author              
Roberts, S, Author
Ntziachristos, V, Author
Westmeyer, GG, Author
Affiliations:
1Department Physiology of Cognitive Processes, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497798              
2Research Group Translational Neuroimaging and Neural Control, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_2528695              
3Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497794              

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 Abstract: Photoacoustic imaging (PAI) is an attractive imaging modality that can volumetrically map the distribution of photoabsorbing molecules with deeper tissue penetration than multiphoton microscopy. To enable dynamic sensing of divalent cations via PAI, we have engineered a new reversible near-infrared probe that is more sensitive to calcium as compared to other biologically relevant cations. The metallochromic compound showed a strong reduction of its peak absorbance at 765 nm upon addition of calcium ions that was translated into robust signal changes in photoacoustic images. Therefore, the heptamethine cyanine dye will be an attractive scaffold to create a series of metallochromic sensors for molecular PAI.

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 Dates: 2016-11
 Publication Status: Published in print
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 Identifiers: DOI: 10.1021/acs.analchem.6b03039
BibTex Citekey: MishraJRNW2016
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Title: Analytical Chemistry
Source Genre: Journal
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Pages: - Volume / Issue: 88 (22) Sequence Number: - Start / End Page: 10785 - 10789 Identifier: -