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  Neurochemical profile of the human cervical spinal cord determined by MRS

Hock, A., Wilm, B., Zandomeneghi, G., Ampanozi, G., Franckenberg, S., Zoelch, N., et al. (2016). Neurochemical profile of the human cervical spinal cord determined by MRS. NMR in Biomedicine, 29(10), 1464-1476. doi:10.1002/nbm.3589.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0000-7968-4 Version Permalink: http://hdl.handle.net/21.11116/0000-0001-1EFC-3
Genre: Journal Article

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Hock, A, Author
Wilm, B, Author
Zandomeneghi, G, Author
Ampanozi, G, Author
Franckenberg, S, Author
Zoelch, N, Author
Wyss, PO1, 2, Author              
De Zanche, N, Author
Nordmeyer-Maßner, J, Author
Kraemer, T, Author
Thali, M, Author
Ernst, M, Author
Kollias, S, Author
Henning, A1, 2, Author              
Affiliations:
1Research Group MR Spectroscopy and Ultra-High Field Methodology, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_2528692              
2Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497794              

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 Abstract: MRS enables insight into the chemical composition of central nervous system tissue. However, technical challenges degrade the data quality when applied to the human spinal cord. Therefore, to date detection of only the most prominent metabolite resonances has been reported in the healthy human spinal cord. The aim of this investigation is to provide an extended metabolic profile including neurotransmitters and antioxidants in addition to metabolites involved in the energy and membrane metabolism of the human cervical spinal cord in vivo. To achieve this, data quality was improved by using a custom-made, cervical detector array together with constructive averaging of a high number of echo signals, which is enabled by the metabolite cycling technique at 3T. In addition, the improved spinal cord spectra were extensively cross-validated, in vivo, post-mortem in situ and ex vivo. Reliable identification of up to nine metabolites was achieved in group analyses for the first time. Distinct features of the spinal cord neurochemical profile, in comparison with the brain neurotransmission system, include decreased concentrations of the sum of glutamate and glutamate and increased concentrations of aspartate, γ-amino-butyric acid, scyllo-inositol and the sum of myo-inositol and glycine.

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 Dates: 2016-10
 Publication Status: Published in print
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 Identifiers: DOI: 10.1002/nbm.3589
BibTex Citekey: HockWZAFZWDNKTEKH2016
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Title: NMR in Biomedicine
Source Genre: Journal
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Pages: - Volume / Issue: 29 (10) Sequence Number: - Start / End Page: 1464 - 1476 Identifier: -