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  Amphiphilic Ditopic Bis-Aqua Gd-AAZTA-like Complexes Enhance Relaxivity of Lipidic MRI Nanoprobes

Gambino, G., Tei, L., Carniato, F., & Botta, M. (2016). Amphiphilic Ditopic Bis-Aqua Gd-AAZTA-like Complexes Enhance Relaxivity of Lipidic MRI Nanoprobes. Chemistry: An Asian Journal, 11(15), 2139-2143. doi:10.1002/asia.201600669.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0000-7988-F Version Permalink: http://hdl.handle.net/21.11116/0000-0000-7989-E
Genre: Journal Article

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Gambino, G1, Author              
Tei, L, Author
Carniato, F, Author
Botta, M, Author
Affiliations:
1Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497794              

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 Abstract: Two amphiphilic mono- and dimeric GdAAZTA-like chelates composed of stable bis-aquo GdIII complexes (q=2) linked to one (for the monomer) or two dodecyl aliphatic chains (for the dimer) were synthesized. Both chelates showed high relaxivity when incorporated into the lipid bilayer of liposomes or after interaction with human serum albumin (HSA). The ditopic complex shows a significantly decreased internal motion relative to the monomeric complex, associated with an enhanced relaxivity (r1≈60 mm−1 s−1, at 30 MHz and 310 K). The presence of two metal-bound water molecules in fast exchange and the restricted rotational freedom make the relaxivity of this system the highest measured for paramagnetic liposomes.

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 Dates: 2016-08
 Publication Status: Published in print
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 Identifiers: DOI: 10.1002/asia.201600669
BibTex Citekey: GambinoTCB2016
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Title: Chemistry: An Asian Journal
Source Genre: Journal
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Pages: - Volume / Issue: 11 (15) Sequence Number: - Start / End Page: 2139 - 2143 Identifier: -