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  Differential effects of rumination and distraction on ketamine induced modulation of resting state functional connectivity and reactivity of regions within the default-mode network

Lehmann, M., Seifritz, E., Walter, M., Böker, H., Henning, A., Scheidegger, M., et al. (2016). Differential effects of rumination and distraction on ketamine induced modulation of resting state functional connectivity and reactivity of regions within the default-mode network. Social Cognitive and Affective Neuroscience, 11(8), 1227-1235. doi:10.1093/scan/nsw034.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0000-798C-B Version Permalink: http://hdl.handle.net/21.11116/0000-0001-1F00-D
Genre: Journal Article

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Lehmann, M, Author
Seifritz, E, Author
Walter, M, Author              
Böker, H, Author
Henning, A1, 2, Author              
Scheidegger, M, Author
Grimm, S, Author
Affiliations:
1Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497794              
2Research Group MR Spectroscopy and Ultra-High Field Methodology, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_2528692              

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 Abstract: Distraction and rumination are distinct response styles that determine how an individual deals with negative thoughts and feelings. Rumination is accompanied by an elevated self-focus, which is associated with increased resting state functional connectivity and decreased reactivity within the default mode network. Interestingly, the NMDA receptor antagonist ketamine reduces functional connectivity in this network, while its effects on blood oxygenation level-dependent (BOLD) responses during stimulus perception are not known. Ketamine might lead to a more variable processing of the external world with an attenuated self-focus by reducing the resting state connectivity. Here, we used an emotional picture-viewing task in combination with functional magnetic resonance imaging to test the hypothesis that a single ketamine administration to healthy subjects increases BOLD reactivity to negative stimuli. We found a region specific increase in BOLD reactivity in the pregenual anterior cingulate cortex and not in a posterior control region after ketamine compared with placebo administration. Moreover, a linear regression revealed that the increase in BOLD reactivity was more pronounced for subjects with a low ability to apply distraction during negative experiences. Our results implicate that ketamine attenuates a potentially pathological increased self-focus during negative experiences.

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 Dates: 2016-08
 Publication Status: Published in print
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 Identifiers: DOI: 10.1093/scan/nsw034
BibTex Citekey: LehmannSWBHSG2016
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Title: Social Cognitive and Affective Neuroscience
Source Genre: Journal
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Pages: - Volume / Issue: 11 (8) Sequence Number: - Start / End Page: 1227 - 1235 Identifier: -