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  Dorsal Anterior Cingulate Lactate and Glutathione Levels in Euthymic Bipolar I Disorder: 1H-MRS Study

Soeiro-de-Souza, M., Pastorello, B., da Costa Leite, C., Henning, A., Moreno, R., & Garcia Otaduy, M. (2016). Dorsal Anterior Cingulate Lactate and Glutathione Levels in Euthymic Bipolar I Disorder: 1H-MRS Study. International Journal of Neuropsychopharmacology, 19(8), 1-8. doi:10.1093/ijnp/pyw032.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0000-798E-9 Version Permalink: http://hdl.handle.net/21.11116/0000-0004-AAB1-4
Genre: Journal Article

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Soeiro-de-Souza, MG, Author
Pastorello, BF, Author
da Costa Leite, C, Author
Henning, A1, 2, Author              
Moreno, RA, Author
Garcia Otaduy, MC, Author
Affiliations:
1Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497794              
2Research Group MR Spectroscopy and Ultra-High Field Methodology, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_2528692              

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 Abstract: Objective: Oxidative stress and mitochondrial dysfunction are 2 closely integrated processes implicated in the physiopathology of bipolar disorder. Advanced proton magnetic resonance spectroscopy techniques enable the measurement of levels of lactate, the main marker of mitochondrial dysfunction, and glutathione, the predominant brain antioxidant. The objective of this study was to measure brain lactate and glutathione levels in bipolar disorder and healthy controls. Methods: Eighty-eight individuals (50 bipolar disorder and 38 healthy controls) underwent 3T proton magnetic resonance spectroscopy in the dorsal anterior cingulate cortex (2x2x4.5cm3) using a 2-D JPRESS sequence. Lactate and glutathione were quantified using the ProFit software program. Results: Bipolar disorder patients had higher dorsal anterior cingulate cortex lactate levels compared with controls. Glutathione levels did not differ between euthymic bipolar disorder and controls. There was a positive correlation between lactate and glutathione levels specific to bipolar disorder. No influence of medications on metabolites was observed. Conclusion: This is the most extensive magnetic resonance spectroscopy study of lactate and glutathione in bipolar disorder to date, and results indicated that euthymic bipolar disorder patients had higher levels of lactate, which might be an indication of altered mitochondrial function. Moreover, lactate levels correlated with glutathione levels, indicating a compensatory mechanism regardless of bipolar disorder diagnosis.

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 Dates: 2016-08
 Publication Status: Published in print
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 Rev. Method: -
 Identifiers: DOI: 10.1093/ijnp/pyw032
BibTex Citekey: SoeirodeSouzaMPdHC2016
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Title: International Journal of Neuropsychopharmacology
  Other : Int. J. Neuropsychopharmacol.
Source Genre: Journal
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Publ. Info: Cambridge : Cambridge University Press
Pages: - Volume / Issue: 19 (8) Sequence Number: - Start / End Page: 1 - 8 Identifier: ISSN: 1461-1457
CoNE: https://pure.mpg.de/cone/journals/resource/963017835281