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  Resting-state functional MRI in an intraoperative MRI setting: proof of feasibility and correlation to clinical outcome of patients

Roder, C., Charyasz-Leks, E., Breitkopf, M., Decker, K., Ernemann, U., Klose, U., et al. (2016). Resting-state functional MRI in an intraoperative MRI setting: proof of feasibility and correlation to clinical outcome of patients. Journal of Neurosurgery, 125(2), 401-409. doi:10.3171/2015.7.JNS15617.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0000-7996-F Version Permalink: http://hdl.handle.net/21.11116/0000-0000-7997-E
Genre: Journal Article

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Roder, C, Author
Charyasz-Leks, E1, 2, Author              
Breitkopf, M, Author
Decker, K, Author
Ernemann, U, Author
Klose, U, Author
Tatagiba, M, Author
Bisdas, S, Author
Affiliations:
1Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497794              
2Department High-Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497796              

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 Abstract: OBJECTIVE The authors' aim in this paper is to prove the feasibility of resting-state (RS) functional MRI (fMRI) in an intraoperative setting (iRS-fMRI) and to correlate findings with the clinical condition of patients pre- and postoperatively. METHODS Twelve patients underwent intraoperative MRI-guided resection of lesions in or directly adjacent to the central region and/or pyramidal tract. Intraoperative RS (iRS)–fMRI was performed pre- and intraoperatively and was correlated with patients' postoperative clinical condition, as well as with intraoperative monitoring results. Independent component analysis (ICA) was used to postprocess the RS-fMRI data concerning the sensorimotor networks, and the mean z-scores were statistically analyzed. RESULTS iRS-fMRI in anesthetized patients proved to be feasible and analysis revealed no significant differences in preoperative z-scores between the sensorimotor areas ipsi- and contralateral to the tumor. A significant decrease in z-score (p < 0.01) was seen in patients with new neurological deficits postoperatively. The intraoperative z-score in the hemisphere ipsilateral to the tumor had a significant negative correlation with the degree of paresis immediately after the operation (r = −0.67, p < 0.001) and on the day of discharge from the hospital (r = −0.65, p < 0.001). Receiver operating characteristic curve analysis demonstrated moderate prognostic value of the intraoperative z-score (area under the curve 0.84) for the paresis score at patient discharge. CONCLUSIONS The use of iRS-fMRI with ICA-based postprocessing and functional activity mapping is feasible and the results may correlate with clinical parameters, demonstrating a significant negative correlation between the intensity of the iRS-fMRI signal and the postoperative neurological changes.

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 Dates: 2016-08
 Publication Status: Published in print
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 Identifiers: DOI: 10.3171/2015.7.JNS15617
BibTex Citekey: RoderCBDEKTB2016
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Title: Journal of Neurosurgery
Source Genre: Journal
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Pages: - Volume / Issue: 125 (2) Sequence Number: - Start / End Page: 401 - 409 Identifier: -