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  Paramagnetic Lanthanide Chelates for Multicontrast MRI

Cakić, N., Savić, T., Stricker-Shaver, J., Truffault, V., Platas-Iglesias, C., Mirkes, C., et al. (2016). Paramagnetic Lanthanide Chelates for Multicontrast MRI. Chemical Communications, 52(59), 9224-9227. doi:10.1039/C6CC04011J.

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Cakić, N1, 2, Author           
Savić, T2, 3, Author           
Stricker-Shaver, J2, Author           
Truffault, V, Author
Platas-Iglesias, C, Author
Mirkes, C1, Author           
Pohmann, R1, 2, Author           
Scheffler, K1, 2, Author           
Angelovski, G2, 3, Author           
Affiliations:
1Department High-Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497796              
2Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497794              
3Research Group MR Neuroimaging Agents, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_2528691              

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 Abstract: The preparation of a paramagnetic chelator that serves as platform for multicontrast MRI, and can be utilized either as a T1-weighted, paraCEST or 19F MRI contrast agent is reported. Its europium(III) complex exhibits extremely slow water exchange rate which is optimal for the use in CEST MRI. The potential of this platform was demonstrated through a series of MRI studies on tube phantoms and animals.

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 Dates: 2016-07
 Publication Status: Issued
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 Identifiers: DOI: 10.1039/C6CC04011J
BibTex Citekey: CakiSSTPMPSA2016
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Title: Chemical Communications
Source Genre: Journal
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Pages: - Volume / Issue: 52 (59) Sequence Number: - Start / End Page: 9224 - 9227 Identifier: -